要通過癌症藥物臨床研究,其中的一道標準就是藥物有高度效率殺滅癌細胞。292Please respect copyright.PENANAhCzw6dmAl6
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追求高效率無可厚非,但以這個例子中,101個病人中,只有1人見效,是否真的代表要放棄這藥呢?292Please respect copyright.PENANAMW0KnBIkFm
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(圖2)在一次Phase2臨床研究中,Everolimus藥物未能在大部份病人中見得到成效,唯獨在一名病人中出現奇效。292Please respect copyright.PENANAdJpcggKtVs
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圖中紅箭嘴所指的位置為腫瘤所在地。用藥6個月後,腫瘤完全消失,情況一直持續至2年半有多。292Please respect copyright.PENANArw3hJwUYFL
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這個情況下,又是否應該放棄這藥物,就這樣以奇蹟二字來解釋此事作罷呢?292Please respect copyright.PENANAJKAxlAEwqJ
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(圖3)有科學家死心不惜(Ref1),致力研究那名病人為何會對此藥作出如此正面的效果。292Please respect copyright.PENANAsDGWwQcOVf
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最後確認原因是那名病人同時在兩道基因NF2及TSC1出現變異,引致該藥物的機制更能有效針對癌細胞。292Please respect copyright.PENANAzjaP7tEUUF
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那場臨床研究主要是針對膀胱癌病人,而膀胱癌同時會出現這兩種基因變異的機率非常之低,因此研究結果非常參差。292Please respect copyright.PENANA1TFOufJyv8
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但是,倘若將來有其他癌症病人同時擁有這兩道基因變異呢?292Please respect copyright.PENANAdoeJ1G3Jis
如果此藥物能有效應付出現這兩道變異基因的癌症,那麼藥物是否還是值得推出市場呢?292Please respect copyright.PENANAYkyXZ9ncIV
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無論如何,此藥最後在2012及2018年被FDA認可,可用作醫療與TSC基因變異有關的症狀。292Please respect copyright.PENANAuj1obJtYRY
那份科學家死心不惜的研究是否有作出相關功勞,並沒有真接證據可顯示得到。292Please respect copyright.PENANAOL1aBkZZD6
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但這份研究明顯地帶出了一道訊息,就算新藥沒能對大部份的病人見效,亦是值得擺放努力剖析為何會對小部份人見效,分分中可能會有意外的收獲,增進開放藥物的新方向。292Please respect copyright.PENANAN67A98cASK
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。292Please respect copyright.PENANAIpyeTfKU63
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc292Please respect copyright.PENANAiS3gLIddXa
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。292Please respect copyright.PENANABzAPZEiKWj
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Link:292Please respect copyright.PENANAxeGIukuUvT
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio292Please respect copyright.PENANAxcdXHmsufq
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。292Please respect copyright.PENANAPEZ6YI5J47
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https://www.instagram.com/potatopigtongue/292Please respect copyright.PENANADpA3edJyPd
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Ref1:https://pubmed.ncbi.nlm.nih.gov/22923433/
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