這系列的第一集,我們講解了PD1/PDL1的運作原理。464Please respect copyright.PENANAoaVmVZdysY
Link: https://www.penana.com/article/471125464Please respect copyright.PENANALEO5rCrAUX
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第二集我們講述CTLA4與T cell功用的關係。464Please respect copyright.PENANAuOjG8JemcD
Link:https://www.penana.com/article/472480464Please respect copyright.PENANAkOnhU9QQLU
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第三集我們講述增加T cell順利到達癌細胞位置的其中一種手段。464Please respect copyright.PENANAcbIHZj1xnG
https://www.penana.com/article/479229464Please respect copyright.PENANAGnWQzhhdoL
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而這一集我們將講解一道關於檢測阻擋PD1的抗體Pembrolizumab成效的研究。464Please respect copyright.PENANApc7OBnInSs
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關於阻檔PD1的原理及初心,可參閱第一集,其後可直接跳過第二第三集來到第四集本集。464Please respect copyright.PENANAMVnuxwKqVt
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(圖2)現今約只有20%的病人能夠從免疫治療中獲取長遠且持續的正面效果。464Please respect copyright.PENANAB1u3BL26n1
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其有效的程度實屬可圈可點,如果有方法能夠盡快得知免疫治療沒有預期成效的話,那就可以即時轉用其他治療手段,把握時候嘗試用第二種方法入手打擊癌症。464Please respect copyright.PENANAUGxSTZplD4
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對此,有科學家嘗試量度血液中癌細胞的DNA含量,觀察能否藉此方法預判免疫治療的效果(Ref1)。464Please respect copyright.PENANAXJWyS7UFlA
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(圖3)癌細胞DNA之所以會出現在血液中,主要由兩大途徑所成。464Please respect copyright.PENANA7iuynzDX52
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1.癌細胞會利用血液循環系統或者淋巴系統轉移到第二個位置,464Please respect copyright.PENANAyxXcqBMJzu
因此血液會有癌細胞的DNA。464Please respect copyright.PENANAUKqrllBg7w
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2.癌細胞亦會往外釋出名Exosome的物質,裡頭亦含有癌細胞的DNA。464Please respect copyright.PENANAmO50nqJzfv
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在這裡,我們暫稱癌細胞在血液中的DNA為ctDNA,Circulating Tumor DNA。464Please respect copyright.PENANABc4vA6wZVm
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(圖4)圖中為利用阻擋PD1的抗體Pembrolizumab作治療的兩名病人結果。464Please respect copyright.PENANAjQNJVEzODD
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紅線為電腦斷層掃描觀察癌細胞大小的影像,而黑線為量度癌細胞在血液(ctDNA)的含量,可見黑線(量度ctDNA的含量)能夠更快預判免疫治療結果成效。464Please respect copyright.PENANAwF5gqdlMi5
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而且,有另外10名接受免疫治療的病人在初期(服用藥物後6-7星期)錄得ctDNA完全下降,亦同樣能夠比電腦斷層掃描觀察更早一步預判成效。464Please respect copyright.PENANAVCOOOCShi6
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而研究中有45名免疫治療的病人在初期沒有錄得任何的ctDNA跌幅,癌細胞的體積在其後亦沒有明顯縮細。464Please respect copyright.PENANA7dmGwqYSvk
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對比含放射性的電腦斷層掃描,量度血液的ctDNA只需抽取病人的血液便可,明顯簡單且快捷。464Please respect copyright.PENANA7bzz1krMu2
只不過每名病人的ctDNA排組均不一樣,先前需要拿取部份癌細胞組織,才能夠有效設計檢測ctDNA的方針。464Please respect copyright.PENANAZhQwHrCFye
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無論如何,若然日後能有研究進一步確立此方法的成效及可信性,定必大可增加對抗癌症的效益。464Please respect copyright.PENANA7ZPUt8N3Dt
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另一方面,透過檢測血液的DNA來預先得知癌細胞的存在,亦是日後檢驗及預防癌症的主流大方向。464Please respect copyright.PENANAtmk28Kve1A
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。464Please respect copyright.PENANAddfYEtXkBE
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc464Please respect copyright.PENANA44UwpkR5H8
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。464Please respect copyright.PENANAtuYfAZykJx
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Link:464Please respect copyright.PENANA0aKwI39Smd
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio464Please respect copyright.PENANAJPkmeQv7jW
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。464Please respect copyright.PENANA6mSNdJeIFm
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https://www.instagram.com/potatopigtongue/464Please respect copyright.PENANAX7MQx8eiS3
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Ref1:https://www.nature.com/articles/s43018-020-009464Please respect copyright.PENANAifXzwzAuuA