肌肉大概佔據身體重量的40%。272Please respect copyright.PENANAVr8W9yPgfg
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。272Please respect copyright.PENANAKjc4DsqkK4
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。272Please respect copyright.PENANAxCXjdYjXNf
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。272Please respect copyright.PENANAIRxq4NPcWm
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。272Please respect copyright.PENANACcmJUwh912
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。272Please respect copyright.PENANA6G5Xgge1DH
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。272Please respect copyright.PENANA8japfqejeN
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。272Please respect copyright.PENANAmfcYLFpwBK
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。272Please respect copyright.PENANAEsQPNGPAUy
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。272Please respect copyright.PENANARqb8E5WpDM
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。272Please respect copyright.PENANAUd5pnHsQRg
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。272Please respect copyright.PENANA2vhfRpm63w
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc272Please respect copyright.PENANAHHuJxFLVFD
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。272Please respect copyright.PENANAOAgom0SZzK
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Link:272Please respect copyright.PENANASz42XNfjER
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio272Please respect copyright.PENANAJstapZSlyE
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。272Please respect copyright.PENANAZfGvZZrpNr
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059272Please respect copyright.PENANAR2v4iSLfqS