癌細胞從原處走到另一地方(轉移,Metastasis),均需透過血液或淋巴系統作交通渠道。384Please respect copyright.PENANAcWAMrRI61f
384Please respect copyright.PENANAWy4aVq3bDR
384Please respect copyright.PENANAOITVUKlsdI
有不少癌細胞轉移到另一器官後會呈「休養」狀態,不迅速繁殖,而是長期潛伏在另一器官內。384Please respect copyright.PENANAr4fA8fe63e
384Please respect copyright.PENANAaBFWuE1j3p
因此就算沒能檢測得到循環腫瘤細胞的存在,也不百分百等於未來不會出現癌細胞轉移事件。384Please respect copyright.PENANA0X8YR0LclN
384Please respect copyright.PENANAYn5V4hmd7D
384Please respect copyright.PENANACO6WL6tJYB
(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究,發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。384Please respect copyright.PENANAHu3JrdEPoj
384Please respect copyright.PENANAHSVFtL5TzH
384Please respect copyright.PENANAC99JqHz3Qw
目的地所含的NK cell越多,該地方出現癌細胞轉移的機率亦會越低。384Please respect copyright.PENANAr9Vr5cn2ug
384Please respect copyright.PENANAWTDBVmkf3P
之所以會出現這情況,除了是NK cell殺死癌細胞這可能性之外,科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質,誘使癌細胞進入休養狀態,不進行自我繁殖。384Please respect copyright.PENANAZjoXbW4stC
384Please respect copyright.PENANAw1CFjaPbGO
384Please respect copyright.PENANAnkKnsSrOR9
(圖3)奈何,至少在肝臟裡頭,一種名為Hepatic stellate cells會釋出CXCL12物質,CXCL12會阻礙NK cell的生長速度。384Please respect copyright.PENANAo9WY3jhvMZ
384Please respect copyright.PENANABi9hExCtsV
384Please respect copyright.PENANAr365ipRVbL
384Please respect copyright.PENANAr2jQduvLqF
久而久之,便再也沒有足夠的NK cell抑制癌細胞的生長,而當潛伏在另一器官的癌細胞快速繁殖之時,這亦是轉移(Metastasis)被鑑定發生之時。384Please respect copyright.PENANAAnp1ibiZxm
384Please respect copyright.PENANAC5MLHZMfbF
384Please respect copyright.PENANA7yjWJZcVg7
對此,研發藥物或療程確保NK cell長期處於足夠水平,或許是一道避免癌細胞發生轉移的大方向。384Please respect copyright.PENANAeGxCrj6Qja
384Please respect copyright.PENANAQszxm2dlkz
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。384Please respect copyright.PENANARewgJ8IUxd
384Please respect copyright.PENANA319kHMBKm9
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc384Please respect copyright.PENANAVRH4v37k13
384Please respect copyright.PENANAkVHcJY91K9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。384Please respect copyright.PENANAqGx9jPh9N6
384Please respect copyright.PENANAbj8HDLO2q6
Link:384Please respect copyright.PENANA9qgZTASqt3
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio384Please respect copyright.PENANAnuR9ZSfyfR
384Please respect copyright.PENANAJJSAvwGrAT
384Please respect copyright.PENANAxEftTQ4qgr
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。384Please respect copyright.PENANAcT7Xqk2Ltu
384Please respect copyright.PENANABQkWER3c23
Ref1:https://www.nature.com/articles/s41586-021-03614-z384Please respect copyright.PENANAHSHMLF8THl