黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。541Please respect copyright.PENANAkfJaF9Hv3M
541Please respect copyright.PENANA7fq23ednsW
541Please respect copyright.PENANA3YWEM107Bc
它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。541Please respect copyright.PENANAMvucgAul9L
541Please respect copyright.PENANAiT06Dz29t3
(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。541Please respect copyright.PENANA1tuU75SvJp
541Please respect copyright.PENANAkd00QWSAoL
541Please respect copyright.PENANAkfa9OLsuPA
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。541Please respect copyright.PENANAWDrGIvGiU4
541Please respect copyright.PENANAb4UT1ZM5Cx
然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。541Please respect copyright.PENANAJhVpetur9H
541Please respect copyright.PENANAWiDt5BV3B5
(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。541Please respect copyright.PENANApgOsLrBCdr
541Please respect copyright.PENANAIjCUC9awZ8
541Please respect copyright.PENANAsgyt7S5HHp
(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),541Please respect copyright.PENANAdCb5JxW8U5
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。541Please respect copyright.PENANAD8y8dU21q5
541Please respect copyright.PENANAwdUlLOEu7H
541Please respect copyright.PENANAnX6dEi3vde
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。541Please respect copyright.PENANAqdl7WBiujZ
541Please respect copyright.PENANAYWso7cgcU2
541Please respect copyright.PENANALLcgu0Rur1
延伸閱讀:541Please respect copyright.PENANAs5KR1aLqp5
深入淺出–從深海生物中發掘出抗真菌藥物541Please respect copyright.PENANAedlCpqcJoQ
- 分享自 LIHKG 討論區541Please respect copyright.PENANA5RUfBEBW8s
https://lih.kg/2296185541Please respect copyright.PENANAOyYtNLcjTa
541Please respect copyright.PENANAhTPborNTA0
541Please respect copyright.PENANAptFWQBeI2Y
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。541Please respect copyright.PENANALk6PdO7dpL
541Please respect copyright.PENANA1FiR30R0Xo
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc541Please respect copyright.PENANAGUeH0Z9ELw
541Please respect copyright.PENANAUDTH0vmnmb
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。541Please respect copyright.PENANASDBIvusc50
541Please respect copyright.PENANAvMBBLPqDSH
Link:541Please respect copyright.PENANAi7itnRw7EB
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio541Please respect copyright.PENANA0zkUhZa9ZZ
541Please respect copyright.PENANAA7wBhW3IC4
541Please respect copyright.PENANAQ7E1XoVSAS
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。541Please respect copyright.PENANAHyMm49bdYu
541Please respect copyright.PENANA40dhB1fla8
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/541Please respect copyright.PENANAYN2RpOHFLq