減低食慾從而減少進食,某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。824Please respect copyright.PENANAl4y0N1E8V5
824Please respect copyright.PENANANDnipzclzY
824Please respect copyright.PENANA9QcvTjNtF2
一直亦有不少研究試圖探討荷爾蒙與食慾的關係,824Please respect copyright.PENANAVWKEfeZWIB
其中之一的目標就是設計出一款能壓抑食慾的藥物,輔助癡肥或糖尿病人的治療。824Please respect copyright.PENANA7Wro9Duljv
824Please respect copyright.PENANAwZWaGd7Rki
824Please respect copyright.PENANAKFU6pBybaN
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。824Please respect copyright.PENANATq2L6JYamC
824Please respect copyright.PENANA5vrpJrtN3i
824Please respect copyright.PENANAJO846ccIax
以非常簡化的角度來說,在飽肚狀態下,含有MC4R蛋白質的神經細胞便會受到刺激,我們的食慾亦會隨之受到壓抑。824Please respect copyright.PENANAMV8SDgL1W3
824Please respect copyright.PENANAwvOu0KoRnd
相反,在飢餓狀態下,含有MC4R蛋白質的神經細胞便會受到壓抑,我們的食慾亦會隨之而來。824Please respect copyright.PENANAVoTCOiq0yx
824Please respect copyright.PENANAM2bsyt3DbI
老鼠缺乏MC4R蛋白質的話,體重亦會明顯上升。824Please respect copyright.PENANAaueDv5wXeI
而MC4R的蛋白質因基因變異而導致部份功能的喪失,亦能在不少癡肥人士身上記錄得到。824Please respect copyright.PENANAKxiAVBguAs
824Please respect copyright.PENANACU1NxWwXD6
824Please respect copyright.PENANAIunvJwdZkb
(圖3)刺激MC4R,便能減低食慾,減低食慾,便能減低進食量,有助對抗癡肥。824Please respect copyright.PENANA0eHfqJM77m
824Please respect copyright.PENANAmEk3HxjaB6
824Please respect copyright.PENANAUEudqJtDk0
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用,不得不終止研究及停止發展。824Please respect copyright.PENANA7hCJVH4rtZ
824Please respect copyright.PENANA1o4TDHVvg1
而好消息的是,最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide,並沒有血壓上升的副作用,在符合對應的條件下可用作體重管理之用。824Please respect copyright.PENANAgqfleQEo2m
824Please respect copyright.PENANAGFSpDSCM4W
824Please respect copyright.PENANAJya00kus9w
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。824Please respect copyright.PENANApDBguzaz4R
824Please respect copyright.PENANAwJwVHz38kk
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc824Please respect copyright.PENANAYFCFjcrm3l
824Please respect copyright.PENANA4Z8HIVl6NN
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。824Please respect copyright.PENANAaIseYtmi1f
824Please respect copyright.PENANAo4GRJqTxha
Link:824Please respect copyright.PENANAKkNHLGJ2rL
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio824Please respect copyright.PENANABkvG29qzMj
824Please respect copyright.PENANAf96G2iustO
824Please respect copyright.PENANAkWjqx4tJ3i
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。824Please respect copyright.PENANAVzCkQfcfAg
824Please respect copyright.PENANAFKXXpiAuPp
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/824Please respect copyright.PENANAUWs12bfVSp
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466824Please respect copyright.PENANAuXSUBctxj2
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/824Please respect copyright.PENANABv2qy0Kqo9
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/824Please respect copyright.PENANAWHeG35Ghan
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/824Please respect copyright.PENANAY1vFqu1sf9