不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。338Please respect copyright.PENANAvrwwzzn7Nh
338Please respect copyright.PENANAMyd67fy2Uq
338Please respect copyright.PENANAZnRZZmDDLp
與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。338Please respect copyright.PENANAy53JFs1QZc
338Please respect copyright.PENANAvHa21oHMhG
(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。338Please respect copyright.PENANAe5wuEOPIIA
338Please respect copyright.PENANAGY8lpHbgRT
338Please respect copyright.PENANALYDuDtSDVt
338Please respect copyright.PENANAfwm4iGnyFx
(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。338Please respect copyright.PENANA5sk4LCyYDe
338Please respect copyright.PENANAISx4doa7hx
338Please respect copyright.PENANAklsMMlohR8
PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。338Please respect copyright.PENANAi72XIrVRfk
338Please respect copyright.PENANAtrc2VHjiK0
只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。338Please respect copyright.PENANAGhZmZFm9Ej
338Please respect copyright.PENANAPlYzwEPTjj
這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。338Please respect copyright.PENANADkGu3WT6l0
338Please respect copyright.PENANAR1QvmyroeQ
338Please respect copyright.PENANAwJgnRAqN6z
癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。338Please respect copyright.PENANAP4qpH14wq0
338Please respect copyright.PENANAe4QN5RFE9U
因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。338Please respect copyright.PENANAHztSD9v7UB
338Please respect copyright.PENANAjVb8sTduAc
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。338Please respect copyright.PENANACSqZdKTXdD
338Please respect copyright.PENANAhtgqcHawnr
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc338Please respect copyright.PENANAv5I62fIQUY
338Please respect copyright.PENANAantspGMBGb
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。338Please respect copyright.PENANAvNLwXiC6J6
338Please respect copyright.PENANANskI2o0hoS
Link:338Please respect copyright.PENANA0pnqluMCj7
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio338Please respect copyright.PENANAYOR9rPfZAu
338Please respect copyright.PENANAQRgsd6jphD
338Please respect copyright.PENANAcd3TSnXhht
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。338Please respect copyright.PENANAuAwUs7JYgT
338Please respect copyright.PENANARB58KxEXbX
Ref1:https://www.nature.com/articles/nature13528338Please respect copyright.PENANAfASjUyIu5a