藥物的效用有時候因人而異,其中一道原因,可以歸究於每個人體內的腸道細菌品種有所不同所致。288Please respect copyright.PENANAJ5vPn1mSXS
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(圖2)口服藥物要抵達血管循環系統的話,無可避免將會途經我們的腸道。288Please respect copyright.PENANAkqOj42XC2w
而我們腸道的細菌有能力改造或代謝藥物,因而改變藥物結構及其效用。288Please respect copyright.PENANAxSg0GMOPbE
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(圖3)有科學家找來人體最為常見的76種腸道細菌品種,與271款不同界別常用的藥物共同放在一起12小時。288Please respect copyright.PENANALc1nJTA0cQ
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最終發現,271款藥物中,有多達176款藥物的濃度在被至少一種腸道細菌影響下,濃度減少了20%;288Please respect copyright.PENANAUohn5AppyY
而這些腸道細菌品種每款可以代謝11-95款藥物不等。288Please respect copyright.PENANAnM8DpLicfk
288Please respect copyright.PENANAzs7eSEQgAJ
用上老鼠作動物模型,科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物,引證腸道細菌影響藥物吸收的理念。288Please respect copyright.PENANAjwF2GVCLrc
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倘若你腸道恰巧住有細菌A,而細菌A又有能力吸收你所口服的藥物,那麼藥效便有可能會大大減低。288Please respect copyright.PENANAQcroMCDteT
288Please respect copyright.PENANAx7NqeYpErf
血液注射而非口服的藥物將有機會不受此限,因為藥物並不需一定要經過腸道裡頭。288Please respect copyright.PENANAI26TCslii6
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。288Please respect copyright.PENANAwnIwKDJCKI
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc288Please respect copyright.PENANARJDvbXzo5x
288Please respect copyright.PENANA8olVS6F4Uw
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。288Please respect copyright.PENANAxAM8rNU23Q
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Link:288Please respect copyright.PENANAPnwgQUTd0i
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio288Please respect copyright.PENANAoyhMfxWtFE
288Please respect copyright.PENANAG1c0B0onAj
288Please respect copyright.PENANAXeEn6pzY7w
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。288Please respect copyright.PENANAdKxhE1o5W7
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Ref1:https://www.nature.com/articles/s41586-019-1291-3288Please respect copyright.PENANAzkQ7IMz06p