日照工作的時候,我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。542Please respect copyright.PENANAWlgXxJLcLx
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在睡覺尤其是深層睡眠的時候,我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間, β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈,離開大腦。542Please respect copyright.PENANAmDqsf5VGk1
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夜間工作而日照時間睡覺會否達到同樣效果,暫時未有人體確實數據可以證實。542Please respect copyright.PENANATcQhnbzhkG
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(圖2)睡覺時份,位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助,抵達靜脈排出腦外;542Please respect copyright.PENANAMreHB5MyD7
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另有研究指出(Ref1),部份的麻醉藥亦能促成同等效果。542Please respect copyright.PENANAopi4kRBpYI
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淋巴系統(Lymphatic System)是排除廢物的系統,基於排除Aβ需要透過星狀細胞的幫助,學術界把整套系統命名為Glympathic system,取其Glial Cell(神經膠質細胞)及Lymphatic System(淋巴系統)的結合,雖則整個機制並沒有淋巴系統的參與(Ref5)。542Please respect copyright.PENANAZyw0f2ht64
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年老以及神經退化症狀的患者,Glympathic system效率大幅減低,因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話,亦會影響睡眠的質素,形成惡性循環(Ref6)。542Please respect copyright.PENANAY7hzev5yXK
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對比年輕人士,年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話,患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。542Please respect copyright.PENANAXOVGAV3xmB
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(圖3)為作進一步了解睡覺與腦部Aβ水平的關係,有研究(Ref2)找來20名人士,分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境,繼而量度Aβ水平。542Please respect copyright.PENANAyVAKHw1pZ5
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兩種測驗環境之間,測試者平均相隔15日分別進行。結果得出,不論性別歲數,通宵一晚平均將會導致5%的Aβ上升。542Please respect copyright.PENANAPhEZ6VxCP4
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(圖4)另外,他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者,發現睡眠質素越高的話,Aβ的移除比率亦會越大。542Please respect copyright.PENANAs5R6X25ZL8
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只不過,亦有研究指出睡眠時數少於5小時或多於11的話,認知能力會有衰退傾向,但未知與Aβ是否有關。542Please respect copyright.PENANAiu31A7TPnO
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長遠而言,通宵會導致Aβ在腦部的聚積,增加患上神經退化症狀的機會,情況許可的話,可免就則免。542Please respect copyright.PENANAx30HnvsuSS
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Ref1:https://advances.sciencemag.org/content/5/2/eaav5447542Please respect copyright.PENANAk9RynNhosv
Ref2:https://www.pnas.org/content/115/17/4483542Please respect copyright.PENANAlkxbSItFzK
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/542Please respect copyright.PENANAnoAAVLcAML
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/542Please respect copyright.PENANAg57dPq2kzp
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/542Please respect copyright.PENANAJKX6gj2hB1
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13