癌細胞從原位轉移到另一器官,亦即是Metastasis,是癌病患者主要的死因。293Please respect copyright.PENANAY51c9W0t4P293Please respect copyright.PENANAOcrx0eDnNn
293Please respect copyright.PENANAs6j173hZuA
「有趣的是」,癌細胞雖近乎不會轉移到肌肉位置裡頭,但卻能從遠處釋放物質,經由血管抵達肌肉位置,催使肌肉萎縮,亦即是癌症惡病質(cancer cachexia)。293Please respect copyright.PENANAgAfmqibQA4
293Please respect copyright.PENANAPEngV67pOG
(圖2)肌肉萎縮不但之令病人變得虛弱,難以接近正常劑量的化療,更為致命的是,當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候,病人便會因呼吸困難等問題而逝死。293Please respect copyright.PENANAHj9h6kCDgV293Please respect copyright.PENANAHHXzK3fa4J
293Please respect copyright.PENANAKwdpCtUsWT
早在1858年已有科學家指出cancer cachexia的存在,但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。293Please respect copyright.PENANAxvLWhk8XrW
293Please respect copyright.PENANAltOXmakaiX
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia,普遍均是從營養方面入手。293Please respect copyright.PENANAxVLnMq4N96293Please respect copyright.PENANAHMdaNSyCRp
293Please respect copyright.PENANAQAPvNUkDXd
但結果大多數是只能夠增加病人的脂肪組織,而沒能夠填補已萎縮的肌肉。293Please respect copyright.PENANA35nmxzYp4z
293Please respect copyright.PENANAkGsxnq4r49
有一點值得注意的是,肌肉細胞並非是死去,純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快,因而形成萎縮。293Please respect copyright.PENANAVsVkIEwSpb
293Please respect copyright.PENANAvSApijdvtg
293Please respect copyright.PENANAB6F8oBSUbW
(圖4)從研究Cancer cachexia的老鼠模型中可以看到,患癌的老鼠不但更為細小,其手腕的握力度亦有所下降。293Please respect copyright.PENANAEhx5bJ9ROz293Please respect copyright.PENANAAa1UxWUUsk
293Please respect copyright.PENANA73nqhdgmfn
觀察肌肉細胞橫切面的面積時,亦可以看到肌肉細胞的面積明顯有所縮細。293Please respect copyright.PENANArZPWqk2FOt
293Please respect copyright.PENANAcMXLUfSBkk
293Please respect copyright.PENANA3E49D2Ll9N
293Please respect copyright.PENANAK7srGMu70o
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。293Please respect copyright.PENANA5ZjIVPpnew
293Please respect copyright.PENANADC1ntXjIDa
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。293Please respect copyright.PENANAgQbJ3T1B15
293Please respect copyright.PENANASPQcTE6mBw
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc293Please respect copyright.PENANASeoyNzdxpg
293Please respect copyright.PENANA8fos5SA8Dg
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。293Please respect copyright.PENANABWGpWpQPDy
293Please respect copyright.PENANAkbNWKZOJ5x
Link:293Please respect copyright.PENANAcMlWRAgbfC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio293Please respect copyright.PENANAou75wQN3UI
293Please respect copyright.PENANAzi5pGpZOHZ
293Please respect copyright.PENANA3vLFJ3Ygx1
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。293Please respect copyright.PENANAnyttcjrY3p
293Please respect copyright.PENANAqbgrOpZpdk
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/293Please respect copyright.PENANAK05cmWtWGi