癌細胞從原處走到另一地方(轉移,Metastasis),均需透過血液或淋巴系統作交通渠道。354Please respect copyright.PENANAN3O0SQUcGL
354Please respect copyright.PENANAPIktQGxoRu
354Please respect copyright.PENANApPz9fWqk0E
有不少癌細胞轉移到另一器官後會呈「休養」狀態,不迅速繁殖,而是長期潛伏在另一器官內。354Please respect copyright.PENANAWvTKQV3XQJ
354Please respect copyright.PENANAW9KLOTIVvP
因此就算沒能檢測得到循環腫瘤細胞的存在,也不百分百等於未來不會出現癌細胞轉移事件。354Please respect copyright.PENANAH6OHzQw5L1
354Please respect copyright.PENANAFaojY1wwW5
354Please respect copyright.PENANA4SPKRLVDqf
(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究,發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。354Please respect copyright.PENANAWhtPcOoVqt
354Please respect copyright.PENANADuXZ01CK0L
354Please respect copyright.PENANA8jbL5kmG4Y
目的地所含的NK cell越多,該地方出現癌細胞轉移的機率亦會越低。354Please respect copyright.PENANA3ONPp6pf1A
354Please respect copyright.PENANAGoHN0z6jnn
之所以會出現這情況,除了是NK cell殺死癌細胞這可能性之外,科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質,誘使癌細胞進入休養狀態,不進行自我繁殖。354Please respect copyright.PENANAM37R3jAsM4
354Please respect copyright.PENANAxCLS15agZg
354Please respect copyright.PENANAMvShWCx1Gg
(圖3)奈何,至少在肝臟裡頭,一種名為Hepatic stellate cells會釋出CXCL12物質,CXCL12會阻礙NK cell的生長速度。354Please respect copyright.PENANAX1lN7wYQP7
354Please respect copyright.PENANAmyVzYMWBo3
354Please respect copyright.PENANAtINC8Io8ww
354Please respect copyright.PENANAYNNFpwohfx
久而久之,便再也沒有足夠的NK cell抑制癌細胞的生長,而當潛伏在另一器官的癌細胞快速繁殖之時,這亦是轉移(Metastasis)被鑑定發生之時。354Please respect copyright.PENANAmeZxCNqoOf
354Please respect copyright.PENANAh1r2zb4LDt
354Please respect copyright.PENANA8dtEXj7slU
對此,研發藥物或療程確保NK cell長期處於足夠水平,或許是一道避免癌細胞發生轉移的大方向。354Please respect copyright.PENANAK2XtFOhqdf
354Please respect copyright.PENANAgENOBKHwOQ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。354Please respect copyright.PENANAk9XM046eRA
354Please respect copyright.PENANArlG7jHUiul
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc354Please respect copyright.PENANAmCT1ZK5VJy
354Please respect copyright.PENANA0Y2Ym9MtHm
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。354Please respect copyright.PENANAG8hi7uNdH1
354Please respect copyright.PENANAfjDMqerBeH
Link:354Please respect copyright.PENANAE6ZWb2Gjpq
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio354Please respect copyright.PENANAAXGG7bkBLy
354Please respect copyright.PENANAR4i8JV93Zt
354Please respect copyright.PENANAMyTikOSuKV
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。354Please respect copyright.PENANA5c7kXLKaFf
354Please respect copyright.PENANA1Vnf0n2drq
Ref1:https://www.nature.com/articles/s41586-021-03614-z354Please respect copyright.PENANAChxtpfLS45