我們身體的各部份均是由細胞組成，眼睛晶片也自當然不例外。797Please respect copyright.ＰＥＮＡＮＡHezkhY5sUB
但細胞裡頭有著各式各樣的細胞器官，例如負責製造能源的粒線體(mitochondria)、收藏DNA的細胞核(nucleus)等，它們顯然並不是透明的。797Please respect copyright.ＰＥＮＡＮＡUYmhoL6Idp
797Please respect copyright.ＰＥＮＡＮＡDkGeoohkKR
究竟身體有甚麼方法可以製造透明且能讓光線通過的眼鏡晶片呢?797Please respect copyright.ＰＥＮＡＮＡbDzGcBKJV5
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(圖2)答案很簡單，就是把那些細胞器官通通摧毀。797Please respect copyright.ＰＥＮＡＮＡy4JuZiN24q
797Please respect copyright.ＰＥＮＡＮＡsglPDBDTxJ
797Please respect copyright.ＰＥＮＡＮＡd31VqMueSy
從圖中可見，晶片的外圍有著表皮細胞(Epithelial cells)以及纖維細胞(Fibre cells)，唯獨是中間區域的細胞，它們的細胞器官均接近得消失得一乾二淨。797Please respect copyright.ＰＥＮＡＮＡOM3XLa3uor
797Please respect copyright.ＰＥＮＡＮＡZMKMN3emAf
797Please respect copyright.ＰＥＮＡＮＡuiaoAI5kgs
(圖3)有科學家利用班馬魚作動物模型，並將兩款細胞器官分別染成綠色及紅色。797Please respect copyright.ＰＥＮＡＮＡgtoJhBKoye
797Please respect copyright.ＰＥＮＡＮＡXA7HEOBWP3
797Please respect copyright.ＰＥＮＡＮＡR0ZS0R2dHs
從圖中可見，直至班馬魚受精後約59小時左右，綠色及紅色均分別清晰可見及有著其獨特的分佈，表示兩款細胞器官非常健在。797Please respect copyright.ＰＥＮＡＮＡOEkPCotCz7
但在約60小時打後，紅色和綠色開始有著衰退的現象，亦即表示細胞器官開始逐漸被受摧毀。797Please respect copyright.ＰＥＮＡＮＡRdiA37xuSA
797Please respect copyright.ＰＥＮＡＮＡdUTDz4dzYf
797Please respect copyright.ＰＥＮＡＮＡLkmFetRDDo
(圖4)找出眼睛晶片的細胞器官被受摧毀的時段後，研究人員便著手進行一系列的實驗，797Please respect copyright.ＰＥＮＡＮＡ1GM9UbYFWv
並發現名為plaat的蛋白質負責在細胞器官的外膜進行破壞，因而引發細胞器官摧毀的過程。797Please respect copyright.ＰＥＮＡＮＡ6rkvNFaIuQ
797Please respect copyright.ＰＥＮＡＮＡ3fHLozHNRT
797Please respect copyright.ＰＥＮＡＮＡSnYAVVmC0L
圖中為班馬魚的眼睛晶片，可見因為缺乏plaat蛋白質的緣故，細胞器官沒能完整摧毀，其晶片亦變得相對上混濁及不透光，影像亦較為不清晰。797Please respect copyright.ＰＥＮＡＮＡTc2TPs1kep
797Please respect copyright.ＰＥＮＡＮＡzxM5tbjlOM
797Please respect copyright.ＰＥＮＡＮＡ2OV2W9hNqf
(圖5)除班馬魚外，研究人員亦有利用老鼠進行實驗。797Please respect copyright.ＰＥＮＡＮＡfRMTNNBqU7
797Please respect copyright.ＰＥＮＡＮＡWHeV6y7dWf
797Please respect copyright.ＰＥＮＡＮＡ56zbXOCu5Q
跟班馬魚一樣，缺乏plaat蛋白質的老鼠眼睛晶片變得混濁及不透光，並影響視線。797Please respect copyright.ＰＥＮＡＮＡrLdcFge2gI
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797Please respect copyright.ＰＥＮＡＮＡ8YH9Ik6qWw
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797Please respect copyright.ＰＥＮＡＮＡHFsgRa0Ei2
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。797Please respect copyright.ＰＥＮＡＮＡC5lmYoYgtf
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc797Please respect copyright.ＰＥＮＡＮＡsBHXcqKovr
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。797Please respect copyright.ＰＥＮＡＮＡH7fAl5MOx0
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Link:797Please respect copyright.ＰＥＮＡＮＡXW9Mc9KWM8
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio797Please respect copyright.ＰＥＮＡＮＡcl8H6bCG4m
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。797Please respect copyright.ＰＥＮＡＮＡNlEWTZk2di
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Ref1:https://www.nature.com/articles/s41586-021-03439-w797Please respect copyright.ＰＥＮＡＮＡxEtYwrbVjL
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