藥物的效用有時候因人而異,其中一道原因,可以歸究於每個人體內的腸道細菌品種有所不同所致。485Please respect copyright.PENANA39Lh8WHDwI485Please respect copyright.PENANACLJExOoz4b
485Please respect copyright.PENANAjbCC83IBCj
(圖2)口服藥物要抵達血管循環系統的話,無可避免將會途經我們的腸道。485Please respect copyright.PENANAMiCiBmAQkZ
而我們腸道的細菌有能力改造或代謝藥物,因而改變藥物結構及其效用。485Please respect copyright.PENANA4j3AJaykBS485Please respect copyright.PENANAyLyrmE22nk
485Please respect copyright.PENANAyfjEOHsO6J
485Please respect copyright.PENANAEMWzBeIvc4
485Please respect copyright.PENANAAMPnCjoMbQ
(圖3)有科學家找來人體最為常見的76種腸道細菌品種,與271款不同界別常用的藥物共同放在一起12小時。485Please respect copyright.PENANAY8jErgxvZK485Please respect copyright.PENANASKPVgANpwy
485Please respect copyright.PENANAfBzaBDPRsC
最終發現,271款藥物中,有多達176款藥物的濃度在被至少一種腸道細菌影響下,濃度減少了20%;485Please respect copyright.PENANApHsbxfSdr0
而這些腸道細菌品種每款可以代謝11-95款藥物不等。485Please respect copyright.PENANARVaUHvQUMM
485Please respect copyright.PENANAHfzwXSyD0C
用上老鼠作動物模型,科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物,引證腸道細菌影響藥物吸收的理念。485Please respect copyright.PENANAhHLPD0Y1x5
485Please respect copyright.PENANAgrfZxH1YL3
倘若你腸道恰巧住有細菌A,而細菌A又有能力吸收你所口服的藥物,那麼藥效便有可能會大大減低。485Please respect copyright.PENANAQCxYuSLJJb
485Please respect copyright.PENANAmu1Vvb8Fw8
血液注射而非口服的藥物將有機會不受此限,因為藥物並不需一定要經過腸道裡頭。485Please respect copyright.PENANADKHGFMEkoq
485Please respect copyright.PENANASyhvIk7hWc
485Please respect copyright.PENANAKBgUtvSTUN
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。485Please respect copyright.PENANA4C3y1TG3Gp
485Please respect copyright.PENANAkEv4mrynnw
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc485Please respect copyright.PENANAo8X02uHRz8
485Please respect copyright.PENANAnV4ddW7V1j
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。485Please respect copyright.PENANAkjoKDjVLBD
485Please respect copyright.PENANAsgoA9s4SX0
Link:485Please respect copyright.PENANAuUSJWHoimq
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio485Please respect copyright.PENANAXUKEjD9iZE
485Please respect copyright.PENANAoTnrVMfPhV
485Please respect copyright.PENANAVySEc2BAD2
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。485Please respect copyright.PENANAr01n2VPBQk
485Please respect copyright.PENANAcLvTLBiKb1
Ref1:https://www.nature.com/articles/s41586-019-1291-3485Please respect copyright.PENANAlWqD9iIPp4