肌肉大概佔據身體重量的40%。247Please respect copyright.PENANAXE8bq6pTau
247Please respect copyright.PENANAzVVo9Z5C2K
247Please respect copyright.PENANAymvGBOSfkU
踏入50歲後,平均每10年就會有15-30%的肌肉流失。247Please respect copyright.PENANAhwkgm0CbKd
247Please respect copyright.PENANAyVKgEQNCbs
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。247Please respect copyright.PENANAIqQKGFKOYO
247Please respect copyright.PENANAQ2GrVHCDoj
247Please respect copyright.PENANAaUclQWMASn
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。247Please respect copyright.PENANAGsSlw7t9YJ
247Please respect copyright.PENANAmmXMwg5Bu0
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。247Please respect copyright.PENANAlNBJss7fUo
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。247Please respect copyright.PENANAUTmkepesoq
247Please respect copyright.PENANAshBSdpru0O
247Please respect copyright.PENANAYy8U4JOScG
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。247Please respect copyright.PENANAAHLjL6bvJ3
247Please respect copyright.PENANAkFFU01JVAG
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。247Please respect copyright.PENANAkF9llHaSGA
247Please respect copyright.PENANAxjziw3tvT2
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。247Please respect copyright.PENANAbaAmKxEilK
247Please respect copyright.PENANAlBCGyHQaCf
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。247Please respect copyright.PENANA1WfKgtVaj7
247Please respect copyright.PENANAbsJzvyQZa7
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。247Please respect copyright.PENANAcvsIUQZH4U
247Please respect copyright.PENANAFMve34n6mg
247Please respect copyright.PENANAZ3Gz3S9V8y
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。247Please respect copyright.PENANAINhknsk8Hg
247Please respect copyright.PENANAxaZi68nFsi
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc247Please respect copyright.PENANAMhdElPmuV0
247Please respect copyright.PENANAtRBpKv8reC
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。247Please respect copyright.PENANAagddutn5G6
247Please respect copyright.PENANAqkcYwCHB83
Link:247Please respect copyright.PENANAzPe3msHwgu
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio247Please respect copyright.PENANAQwPc1GO0U1
247Please respect copyright.PENANAWZ3W4IGwcB
247Please respect copyright.PENANAjzDvjKyzul
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。247Please respect copyright.PENANAfFh4C8PHIP
247Please respect copyright.PENANAXCYEFhjmwg
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059247Please respect copyright.PENANAklfxe9ASeO