癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。491Please respect copyright.ＰＥＮＡＮＡRPddZKbUYd
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「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。491Please respect copyright.ＰＥＮＡＮＡqp9OYunmRI
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(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。491Please respect copyright.ＰＥＮＡＮＡfUF5H3aMxr
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早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。491Please respect copyright.ＰＥＮＡＮＡZDiWCYYQ1p
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(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。491Please respect copyright.ＰＥＮＡＮＡSfsRi74olG
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但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。491Please respect copyright.ＰＥＮＡＮＡugR8WTPkCW
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有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。491Please respect copyright.ＰＥＮＡＮＡCKr1mEl0YS
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(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。491Please respect copyright.ＰＥＮＡＮＡyJgetysIfd
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觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。491Please respect copyright.ＰＥＮＡＮＡMjtWxM1lUB
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下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。491Please respect copyright.ＰＥＮＡＮＡ5irkfMHe65
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。491Please respect copyright.ＰＥＮＡＮＡuLS7sVhqi2
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。491Please respect copyright.ＰＥＮＡＮＡZ9K7jAiZgd
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。491Please respect copyright.ＰＥＮＡＮＡSxUFgCI1DJ
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/491Please respect copyright.ＰＥＮＡＮＡGdYTzJocw4
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