要理解為何癌症會導致肌肉萎縮,其中的一道辦法就是對比萎縮肌肉與正常肌肉有甚麼分別,再以推敲其相關的機制。486Please respect copyright.PENANAuwDnnWjgED
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(圖2)研究發現,患癌老鼠的萎縮肌肉中,其名為ZIP14的蛋白質含量特別高企,且在患癌的老鼠但其肌肉並沒有萎縮的情況下, ZIP14的蛋白質含量並沒有顯著提升。486Please respect copyright.PENANAcJTqho4j6b
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(圖3)ZIP14蛋白質的主要作用是把鋅 (Zinc)輸送到細胞裡頭。486Please respect copyright.PENANAhebOM40fjU
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科學家量度因癌症而導致萎縮的肌肉,發現肌肉的鋅 (Zinc)含量的確是比正常肌肉的為多,與其ZIP14蛋白質含量不謀而合。486Please respect copyright.PENANA0pdtMQTtmJ
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(圖4)利用基因工程移除ZIP14蛋白質的話,可以見得到患癌老鼠的肌肉細胞橫切面並沒有顯著的減少。486Please respect copyright.PENANAQp2Q0uTo2K
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再作一系列的實驗後,科學家推斷當癌細胞所釋出的TGFa/b物質到達肌肉位置後,便會引起肌肉ZIP14蛋白質含量上升,因而引起肌肉萎縮。486Please respect copyright.PENANAVrBcMFW9mP
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科學家們現正研究如何針對ZIP14蛋白質來抑制癌症所引致的肌肉萎縮,結果適目而待。486Please respect copyright.PENANAigz7AUsFfi
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Ref1:https://pubmed.ncbi.nlm.nih.gov/29875463/486Please respect copyright.PENANAl6UvI8HXpN