此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。322Please respect copyright.PENANAGtxgEuMekA
322Please respect copyright.PENANAIwSQvY7YCh
利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。322Please respect copyright.PENANA2C95AtoLYI
延伸閱讀:https://www.penana.com/article/500206322Please respect copyright.PENANAHF0S7pqJfb
322Please respect copyright.PENANAnZVRJMPZQY
322Please respect copyright.PENANAGlt651oTiV
CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;322Please respect copyright.PENANAeA5EpgBRaT
在這個層面上,亦即是癌細胞。322Please respect copyright.PENANA0Tl3ZK0DI7
322Please respect copyright.PENANAlVFkoDO0kk
(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。322Please respect copyright.PENANADO8YYh73ty
322Please respect copyright.PENANAdIkGbebmVn
322Please respect copyright.PENANABgkK5dfcPa
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。322Please respect copyright.PENANASP6XUzVVSI
322Please respect copyright.PENANAxy5T6OkYjx
322Please respect copyright.PENANAOFpiGtRYjU
(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。322Please respect copyright.PENANAStZujMJ4oL
322Please respect copyright.PENANADRm3GklezN
322Please respect copyright.PENANAyBcja19Aro
最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。322Please respect copyright.PENANAIlwTewPssy
322Please respect copyright.PENANAZrdMMhPVez
在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。322Please respect copyright.PENANAgq21ulp0sD
322Please respect copyright.PENANAWn9ffrAkQm
這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。322Please respect copyright.PENANAPfKXovGd22
322Please respect copyright.PENANAm3AjdPN1A4
無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。322Please respect copyright.PENANADxF3IN0V1u
322Please respect copyright.PENANAWgyvIBBOCY
322Please respect copyright.PENANANpbJZL4u34
322Please respect copyright.PENANAhzQIF9rD6N
322Please respect copyright.PENANApGihuKQ7SD
322Please respect copyright.PENANAQONAtinplo
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。322Please respect copyright.PENANAr318ip8Vxg
322Please respect copyright.PENANArj84hAXRuI
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc322Please respect copyright.PENANAAo1rOsRIUG
322Please respect copyright.PENANAZPVPGM4oSu
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。322Please respect copyright.PENANAHHxSwrB8RV
322Please respect copyright.PENANAuyRFdvci1f
Link:322Please respect copyright.PENANAiu6Zc4QWWb
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio322Please respect copyright.PENANAgCholrIOA1
322Please respect copyright.PENANAdKlqmrYwM8
322Please respect copyright.PENANA5Xd59iNtO5
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。322Please respect copyright.PENANAzckeaxEpaP
322Please respect copyright.PENANAIX4lCXgk1Z
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
322Please respect copyright.PENANAtuPBqC2d3E