最為理想的檢測武漢肺炎方法,當然是要準確同快速兩者兼備,不需任何儀器家用便能做到為之更佳。402Please respect copyright.PENANAMrjVR4WmM9
402Please respect copyright.PENANALEKAfGFVTF
402Please respect copyright.PENANAXZYwMzUYP3
現今最為標準的檢測方法RT-QPCR,但整個過程接近耗時2小時,而且亦需要實驗室PCR儀器及專業人士確認結果的可信性。402Please respect copyright.PENANAljjfo0DJO5
402Please respect copyright.PENANAlLsIK1O3wn
較為快捷但並未全面通行的方法為RT-LAMP,整個過程約耗時30-50分鐘,可套用不同方法展示結果,最高靈敏度比RT-QPCR約低10倍。402Please respect copyright.PENANAhhwfMPCgQi
402Please respect copyright.PENANALW5qrQ3wxJ
整個過程受著需要在攝氏65度運行的限制,距離家用化仍擁有著些許的不便。402Please respect copyright.PENANAE8BAwr6rqR
402Please respect copyright.PENANANZ9nheI1de
402Please respect copyright.PENANAwuJ1zDhkoY
(圖2)最近有科學家研發一套名為SENSR的檢測方法(Ref1),耗時約30-50分鐘,但全程只需在攝氏37度運行!402Please respect copyright.PENANAfgeH53b7rZ
402Please respect copyright.PENANAWufoaRJn8p
402Please respect copyright.PENANAeS72gWwG58
他們嘗試利用最為準確的RT-QPCR方法作出對比,40個樣本之中,有39個達一致結果。402Please respect copyright.PENANAZl6hn8f130
整個檢測方法主要包含四大組件,如圖中所示。402Please respect copyright.PENANA5hXhdnJOX2
402Please respect copyright.PENANAQuyun7Mipn
402Please respect copyright.PENANAHUhh5fifep
(圖3)經過精心的設計,兩隻Probes會辨認武肺病毒RNA前後二段位置。402Please respect copyright.PENANAtmKOtpcE5V
兩隻Probes同時辨認成功後,名為SplintR ligase的蛋白質便會將兩隻Probes連成一起。402Please respect copyright.PENANAvnOp2foJYT
402Please respect copyright.PENANAl1Js2vXdF2
402Please respect copyright.PENANA4JKQsi9u1y
402Please respect copyright.PENANAHSxBwJHgXO
(圖4)連成一起的Probe將會被T7 RNA polymerase 利用,生產出特殊結構的物質。402Please respect copyright.PENANADCmESkgBQE
402Please respect copyright.PENANATqkc79Rhjb
402Please respect copyright.PENANAJixigsR6qH
這些特殊結構物質會Fluroescence Dye結合,發出螢光,而沒有與特殊結構物質結合的Fluroescence Dye則不會發出螢光。402Please respect copyright.PENANAFAeGaULmTX
402Please respect copyright.PENANA661IHvVsgZ
402Please respect copyright.PENANA18EsquuXQ9
(圖5)只要將病人口水及能夠打破病毒外層的化學物與檢測方法組件放在一起,在攝氏37度的環境下,半小時後便能憑著螢光強度獲取結果。402Please respect copyright.PENANAsA6pt0Nk3R
402Please respect copyright.PENANAQkub9OPZ0h
402Please respect copyright.PENANA5jk59pehSL
沒有螢光,意指沒有武肺病毒的存在。402Please respect copyright.PENANApwOUWvnyR6
而螢光越強,則代表武肺病毒數量就越多。402Please respect copyright.PENANAIAa1sk5UKJ
402Please respect copyright.PENANAc6ixN38sKd
若然整套檢測方法能長久地與RT-QPCR的結果吻合的話,甚至能改良至更短時間完成的話,那些健康碼或健康護照的系統便完全成為被科技淘汰、多餘無用的產物。402Please respect copyright.PENANAnXDAo2DJY1
402Please respect copyright.PENANAFqCJZfJVyp
402Please respect copyright.PENANAS2oD5172pO
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。402Please respect copyright.PENANAj2T7afzWph
402Please respect copyright.PENANAtdReg3HUik
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc402Please respect copyright.PENANAS0JWcAfLsW
402Please respect copyright.PENANAprCksyKKt6
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。402Please respect copyright.PENANAEX0yADmkwe
402Please respect copyright.PENANAbqtVK78a5P
Link:402Please respect copyright.PENANAQ9wNuquutC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio402Please respect copyright.PENANAlHZT1RKKAk
402Please respect copyright.PENANAcCF7mvPsZN
402Please respect copyright.PENANAIOT9VM26Te
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。402Please respect copyright.PENANAmCelnCte7G
402Please respect copyright.PENANA7j8GAafN8U
402Please respect copyright.PENANAAKE6gCEv5e
Ref1:https://www.nature.com/articles/s41551-020-00617-5.epdf?sharing_token=jyB1FrYxTMs2zz7531NEC9RgN0jAjWel9jnR3ZoTv0Oek8rnwPluVmxh8oas6RXA_yYuSqspJD8rPlYkIjcQAnYsXIpSHTS1rRw2pBOABq2RcPNywJhYXk5RtoOUasrjInaGxrHnZw-U2KJCVSypN2TLCfr8XdJlRq3q0or2Vs8%3D