癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。465Please respect copyright.ＰＥＮＡＮＡfjkG7IPq9E
465Please respect copyright.ＰＥＮＡＮＡj7zgq0MaZ1
465Please respect copyright.ＰＥＮＡＮＡZQ23JKFiZX
「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。465Please respect copyright.ＰＥＮＡＮＡfWsCzi00Ns
465Please respect copyright.ＰＥＮＡＮＡyFDFWGdKxq
(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。465Please respect copyright.ＰＥＮＡＮＡCkrFka0YxR
465Please respect copyright.ＰＥＮＡＮＡ2YLGoCJI5b
465Please respect copyright.ＰＥＮＡＮＡmiEHdEokZF
早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。465Please respect copyright.ＰＥＮＡＮＡTADVEJVF9i
465Please respect copyright.ＰＥＮＡＮＡWLY6rMdMMr
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。465Please respect copyright.ＰＥＮＡＮＡWDhpYVq4Qi
465Please respect copyright.ＰＥＮＡＮＡdss5VWqhx7
465Please respect copyright.ＰＥＮＡＮＡpi8ioPTuEc
但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。465Please respect copyright.ＰＥＮＡＮＡ0g7uzge8pk
465Please respect copyright.ＰＥＮＡＮＡOaarqkRwZj
有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。465Please respect copyright.ＰＥＮＡＮＡ4n7Z8C4LhZ
465Please respect copyright.ＰＥＮＡＮＡC6jrtoplP1
465Please respect copyright.ＰＥＮＡＮＡ1oCIXPjhHB
(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。465Please respect copyright.ＰＥＮＡＮＡKYMREdK2ws
465Please respect copyright.ＰＥＮＡＮＡRc3d0jKyfy
465Please respect copyright.ＰＥＮＡＮＡz6tCLncuLD
觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。465Please respect copyright.ＰＥＮＡＮＡ1EBQ6S6wYt
465Please respect copyright.ＰＥＮＡＮＡtZkUQ5Ylyz
465Please respect copyright.ＰＥＮＡＮＡWaqvm8XlIj
465Please respect copyright.ＰＥＮＡＮＡ5JLBVI0Dnx
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。465Please respect copyright.ＰＥＮＡＮＡjuoo7qhFGP
465Please respect copyright.ＰＥＮＡＮＡbMpsMPa2gk
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。465Please respect copyright.ＰＥＮＡＮＡY2APD3euoz
465Please respect copyright.ＰＥＮＡＮＡMsHymYeINo
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc465Please respect copyright.ＰＥＮＡＮＡYwirKH0GIq
465Please respect copyright.ＰＥＮＡＮＡnqViR1CR2Z
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。465Please respect copyright.ＰＥＮＡＮＡ5tnMem5qum
465Please respect copyright.ＰＥＮＡＮＡEQPwt05ero
Link:465Please respect copyright.ＰＥＮＡＮＡ4fWOkfgbuT
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio465Please respect copyright.ＰＥＮＡＮＡN9RqvGE0UT
465Please respect copyright.ＰＥＮＡＮＡISgchYD6LB
465Please respect copyright.ＰＥＮＡＮＡjSKwkJLNOJ
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。465Please respect copyright.ＰＥＮＡＮＡTbVzRvEXdr
465Please respect copyright.ＰＥＮＡＮＡVXDbyhKHEy
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/465Please respect copyright.ＰＥＮＡＮＡIFJNGwTwuO
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
