癌細胞所在的環境裡,佈滿各式各樣的細胞。460Please respect copyright.PENANAWoq0cc2zTl460Please respect copyright.PENANAIw0ZGs0juB
460Please respect copyright.PENANAaaZiXIFqAZ
當中有為數不少的是免疫細胞,只可是癌細胞發展出不同的機制躲避免疫細胞的攻勢,因此周遭的免疫細胞並沒能發揮其殺滅不良細胞的功效。460Please respect copyright.PENANA3oziGBPOuI
460Please respect copyright.PENANAErPSYnYnMO
無論如何,它們同在一個環境裡,無可避免要面對一個問題,就是如何分配糧食。460Please respect copyright.PENANA6MkM3RBXJl
460Please respect copyright.PENANA69NdEgeyAr
(圖2)在癌細胞所在的環境裡,以葡萄糖(Glucose)及麩醯胺酸(Glutamine)為營養界別含量最多的兩大元首。460Please respect copyright.PENANACxYzONRNcy460Please respect copyright.PENANAu1jxniyDHw
460Please respect copyright.PENANAqKS113pltJ
研究發現,如果對比單一細胞的營養吸收速度的話,免疫細胞吸取葡萄糖的速度比癌細胞的為快。460Please respect copyright.PENANA3bvaiECX0g
460Please respect copyright.PENANAJRakD6rWW9
反之,癌細胞吸取麩醯胺酸的速度則比免疫細胞的為快。460Please respect copyright.PENANA7hR7jcFYGD
460Please respect copyright.PENANArcuM2Fg2LJ
460Please respect copyright.PENANAluiqCNwHrF
(圖3)重要的是,如果利用藥物阻截兩款細胞吸取麩醯胺酸的話,它們均會啟動機制加快吸收葡萄糖的速度,從而彌補營養所需。460Please respect copyright.PENANAVHeFS8Wlsn460Please respect copyright.PENANAK17KOVdyxa
460Please respect copyright.PENANAT58YtXGnM1
換句話說,它們配備使用及吸收兩種營養的能力,可根據環境供求而隨時變陣。460Please respect copyright.PENANApWSOzFcTkY
460Please respect copyright.PENANABz8j3ouUBO
460Please respect copyright.PENANAm2orl2lykz
(圖4)雖然免疫細胞吸取葡萄糖的速度比癌細胞的為快,但如果計算整個環境的吸收總量的話,基於癌細胞數量多於免疫細胞,癌細胞共吸收環境葡萄糖總量達70%有多,而其餘免疫細胞的吸取量則只佔餘下的30%。460Please respect copyright.PENANA6ftC08xXuP460Please respect copyright.PENANA27rCStm59n
460Please respect copyright.PENANASmIMk8VrUn
亦即是說,依靠葡萄糖吸取量來探測癌細胞存在的技術(FDG-PET),其癌細胞所在的環境至少有30%的訊號是來自免疫細胞,而非癌細胞。460Please respect copyright.PENANA1BiOaFkpMo
460Please respect copyright.PENANAojdoGuf1qo
460Please respect copyright.PENANAN7ab9bP4DQ
460Please respect copyright.PENANAdS3meAz5yL
460Please respect copyright.PENANA0m03vd2ijr
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。460Please respect copyright.PENANApfSXiwsGBA
460Please respect copyright.PENANAT4aQE3GYnv
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc460Please respect copyright.PENANAxsjDEX0JWw
460Please respect copyright.PENANAxeez7WN8nF
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。460Please respect copyright.PENANApudIJRHe0N
460Please respect copyright.PENANAnEYVpkItgB
Link:460Please respect copyright.PENANAbEyBiWGOXM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio460Please respect copyright.PENANAGjtFe84e7V
460Please respect copyright.PENANAbU9RPLurVJ
460Please respect copyright.PENANAS83vMxhjFS
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。460Please respect copyright.PENANAxhhYAqApak
460Please respect copyright.PENANANrRQOqXC69
Ref1https://www.nature.com/articles/s41586-021-03442-1#MOESM3460Please respect copyright.PENANAoVFXmpTAwA