近日有急凍雞翼及其他產品被測量出擁有武肺存在，但武肺能否在雞翼或其他食物上大量繁殖呢？930Please respect copyright.ＰＥＮＡＮＡ1xDp5ZFjkD
930Please respect copyright.ＰＥＮＡＮＡESH8IyVi5a
答案是，不可以。930Please respect copyright.ＰＥＮＡＮＡ33gBRm0mUQ
930Please respect copyright.ＰＥＮＡＮＡfEbhfXQ7sQ
武肺進行大量繁殖的話，必需要借助活生生的細胞幫忙，而其中先決的一步就是要進入細胞體內。930Please respect copyright.ＰＥＮＡＮＡVETF7oJv2Z
930Please respect copyright.ＰＥＮＡＮＡozqVB02DaP
武肺可否入侵細胞，基本上視乎可唔可以達成下列3個條件。930Please respect copyright.ＰＥＮＡＮＡ4P6JgUmmyW
（圖1）930Please respect copyright.ＰＥＮＡＮＡO0W9FZGpy1
930Please respect copyright.ＰＥＮＡＮＡTrrLMYzufA
930Please respect copyright.ＰＥＮＡＮＡDNjp5tFyM1
1. S protein與細胞表面的ACE2觸碰。930Please respect copyright.ＰＥＮＡＮＡTZis1SPrUn
930Please respect copyright.ＰＥＮＡＮＡJHpzmIPBZH
2. 細胞表面ACE2與S protein的形狀吻合，亦即是「啱嘴形」。930Please respect copyright.ＰＥＮＡＮＡ4EYD7otvwS
930Please respect copyright.ＰＥＮＡＮＡ8vTgPPOXtb
3. 細胞表面擁有TMPRSS2蛋白質，能夠對S protein進行切割。930Please respect copyright.ＰＥＮＡＮＡfwCI9q0b75
930Please respect copyright.ＰＥＮＡＮＡonjcHlJTp5
滿足3大條件後，病毒就有能力能夠入侵細胞。930Please respect copyright.ＰＥＮＡＮＡhu1ykGpAVO
當然，入侵細胞後還有很多因素決定武肺能否大量繁殖，但急凍雞翼連活生生的細胞也沒有，根本無可能可以大量繁殖。930Please respect copyright.ＰＥＮＡＮＡlSNRK420yA
930Please respect copyright.ＰＥＮＡＮＡVujMXBr9wz
何謂S protein和ACE2，可到我之前所寫的文章溫故知新。930Please respect copyright.ＰＥＮＡＮＡkqUdKln7Ek
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/9930Please respect copyright.ＰＥＮＡＮＡ0rqjrIOsUr
930Please respect copyright.ＰＥＮＡＮＡSrKaQoksEO
930Please respect copyright.ＰＥＮＡＮＡbjoe5WdEhO
930Please respect copyright.ＰＥＮＡＮＡqzSaIpqB8p
（圖2）930Please respect copyright.ＰＥＮＡＮＡ0TuvJG1jHD
第二點所謂的「啱嘴型」，所指的就是ACE2的形狀能否與武肺的S protein形狀吻合，就好像砌Puzzle一樣，兩者不吻合的話就無法連結一起，勉強亦無幸福。930Please respect copyright.ＰＥＮＡＮＡso3DhiyBWK
930Please respect copyright.ＰＥＮＡＮＡmx6e4b0vkB
如圖中所見，正因為老鼠ACE2唔啱嘴型，所以武肺無法引致老鼠患上肺炎等病徵，袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。930Please respect copyright.ＰＥＮＡＮＡfkP5i3dlxO
930Please respect copyright.ＰＥＮＡＮＡkrToRmIFVh
（Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上，最終無法在牠們的任何器官身上找到武肺，而且亦沒有出現任何病徵，因此斷定牠們並不會受到武肺感染。930Please respect copyright.ＰＥＮＡＮＡH61z3PApVy
930Please respect copyright.ＰＥＮＡＮＡ4UY9TC4aCa
930Please respect copyright.ＰＥＮＡＮＡvOyxUPrS3V
（圖3）930Please respect copyright.ＰＥＮＡＮＡGXoHA9CCnp
關於第三點，肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2（Ref2)，因此將會成為武肺的主要針對對象。930Please respect copyright.ＰＥＮＡＮＡDWdnEjS6Ei
930Please respect copyright.ＰＥＮＡＮＡ52fmipSayT
而心臟(Heart) 同樣擁有一定數量的ACE2，某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。930Please respect copyright.ＰＥＮＡＮＡlEu0UjDGwj
930Please respect copyright.ＰＥＮＡＮＡQbiHC0tisG
930Please respect copyright.ＰＥＮＡＮＡJjNeOXJLSA
而男性器官睪丸(Testis)，亦是ACE2數量較多的器官（圖中沒有列出），所以，嗯......930Please respect copyright.ＰＥＮＡＮＡs91lDfwbfa
930Please respect copyright.ＰＥＮＡＮＡSDBgjngSdq
930Please respect copyright.ＰＥＮＡＮＡ2KaqB0DAwV
930Please respect copyright.ＰＥＮＡＮＡGizaw57nvl
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。930Please respect copyright.ＰＥＮＡＮＡxuizzMF6AZ
930Please respect copyright.ＰＥＮＡＮＡjb08ZzbIdz
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc930Please respect copyright.ＰＥＮＡＮＡCY9ghDzUuX
930Please respect copyright.ＰＥＮＡＮＡX11ERYQFez
同時亦可以在Penana網站裡按「買一嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。930Please respect copyright.ＰＥＮＡＮＡETOOmWPUmN
930Please respect copyright.ＰＥＮＡＮＡqWOgWRJ0W9
Link:930Please respect copyright.ＰＥＮＡＮＡ8k6KM07sN3
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio930Please respect copyright.ＰＥＮＡＮＡLCvdsE3mcV
930Please respect copyright.ＰＥＮＡＮＡgsAuZosu48
930Please respect copyright.ＰＥＮＡＮＡdTiwtOPS0H
有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。930Please respect copyright.ＰＥＮＡＮＡfH6sJsd6tM
930Please respect copyright.ＰＥＮＡＮＡ4OLtyQAWkp
930Please respect copyright.ＰＥＮＡＮＡ2rQ1ZrABTE
930Please respect copyright.ＰＥＮＡＮＡ3adtEskRry
930Please respect copyright.ＰＥＮＡＮＡAuhTEZUTes
930Please respect copyright.ＰＥＮＡＮＡE0yApXtck3
Ref1:https://science.sciencemag.org/content/368/6494/1016930Please respect copyright.ＰＥＮＡＮＡ9g6wOz5Weq
930Please respect copyright.ＰＥＮＡＮＡAvUqxQ3vfe
Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig1930Please respect copyright.ＰＥＮＡＮＡpGwzEOqBjQ
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
