此篇文章並非意圖貶損任何癌症的治療方法，純粹是轉述一宗失敗個案及其原因，探討從失敗中學習的過程。552Please respect copyright.ＰＥＮＡＮＡz0DKAbrpXB
552Please respect copyright.ＰＥＮＡＮＡlDTZVzVGd6
利用免疫治療法來對抗癌症，早前我們已經花了不少篇幅講述。552Please respect copyright.ＰＥＮＡＮＡkVpciRWHtP
延伸閱讀:https://www.penana.com/article/500206552Please respect copyright.ＰＥＮＡＮＡQo06lxvfRr
552Please respect copyright.ＰＥＮＡＮＡFX6U04EjVh
552Please respect copyright.ＰＥＮＡＮＡZA84BxUlLd
CAR T cell治療法，就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件，引導它們更有效率殲滅對應的細胞;552Please respect copyright.ＰＥＮＡＮＡF5zjQ5ll2h
在這個層面上，亦即是癌細胞。552Please respect copyright.ＰＥＮＡＮＡWkBAYmG5su
552Please respect copyright.ＰＥＮＡＮＡHK8sc8r956
(圖2)2010年，一名39歲女士患上腸癌，久經不同款式化療亦未見成效，故此便嘗試當時候較為新穎的CAR T cell 療法。552Please respect copyright.ＰＥＮＡＮＡGbJ4Wp8WpT
552Please respect copyright.ＰＥＮＡＮＡCRByMc0fQM
552Please respect copyright.ＰＥＮＡＮＡdifLhOPS2P
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質，所以其治療的方式便是從她身上取得免疫細胞，再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell，再以將這些CAR T cell注入她體內，盼望這些CAR T cell會殲滅腸癌細胞。552Please respect copyright.ＰＥＮＡＮＡtvjFlLxYFw
552Please respect copyright.ＰＥＮＡＮＡ6PDTQ86UI0
552Please respect copyright.ＰＥＮＡＮＡYPxPDWHaAc
(圖3)不幸的是，注入CAR T cell後的15分鐘，她出現呼吸困難等症狀，隨之亦送入ICU作出治療，唯5日後亦與世祥辭。552Please respect copyright.ＰＥＮＡＮＡqyW82Lo6OE
552Please respect copyright.ＰＥＮＡＮＡVx1QaYOPfA
552Please respect copyright.ＰＥＮＡＮＡ8YkjwaHZXs
最後經驗屍及分析各種數據後，相信是因為肺部含有微量ERBB2蛋白質，在抵達癌細胞位置前，那些CAR T cell率先與持有ERBB2的肺部細胞結合，產生過量的免疫反應，引致肺部器官發炎及衰竭，導致氧氣沒能輸送至各器官位置。552Please respect copyright.ＰＥＮＡＮＡlz4KGlfPOx
552Please respect copyright.ＰＥＮＡＮＡqlKBkYNCdK
在這手術進行之前，亦有不少針對ERBB2的CAR T cell人體試驗，箇中並沒有發生相同症狀。552Please respect copyright.ＰＥＮＡＮＡntEPFgP4su
552Please respect copyright.ＰＥＮＡＮＡkO2rFtirci
這相信是因為是次手術為了希望能夠順利殲滅癌細胞，其注入的T cell數量被以往實驗過多，因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。552Please respect copyright.ＰＥＮＡＮＡxcrZkPDkJv
552Please respect copyright.ＰＥＮＡＮＡKEHPy77ijZ
無論如何，從這之經驗中可得知，ERBB2顯然並不是一道針對癌細胞的理想對象。552Please respect copyright.ＰＥＮＡＮＡZgLwZdFeZ1
552Please respect copyright.ＰＥＮＡＮＡFHrdtGqGjN
552Please respect copyright.ＰＥＮＡＮＡxyc9RYqfP3
552Please respect copyright.ＰＥＮＡＮＡ9AdPCVk1wo
552Please respect copyright.ＰＥＮＡＮＡQVNQIcd9Eo
552Please respect copyright.ＰＥＮＡＮＡ4ri0V9UzGm
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。552Please respect copyright.ＰＥＮＡＮＡlV2cHbhTy8
552Please respect copyright.ＰＥＮＡＮＡY0JFv1tD7F
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc552Please respect copyright.ＰＥＮＡＮＡ32Xdql6wdH
552Please respect copyright.ＰＥＮＡＮＡ2g3cE4Sq9k
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。552Please respect copyright.ＰＥＮＡＮＡEDlhgOZu7Z
552Please respect copyright.ＰＥＮＡＮＡMpMLWmRYdB
Link:552Please respect copyright.ＰＥＮＡＮＡmaxrvBLLdY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio552Please respect copyright.ＰＥＮＡＮＡA5gu1BeFtV
552Please respect copyright.ＰＥＮＡＮＡK29hBoY8bJ
552Please respect copyright.ＰＥＮＡＮＡzkVddojOhU
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。552Please respect copyright.ＰＥＮＡＮＡtngHtARIvl
552Please respect copyright.ＰＥＮＡＮＡQm2rSKXSM1
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
552Please respect copyright.ＰＥＮＡＮＡrnsawCeAZQ
