此篇文章並非意圖貶損任何癌症的治療方法，純粹是轉述一宗失敗個案及其原因，探討從失敗中學習的過程。577Please respect copyright.ＰＥＮＡＮＡJWpC2AL45o
577Please respect copyright.ＰＥＮＡＮＡJBwlWOKSTG
利用免疫治療法來對抗癌症，早前我們已經花了不少篇幅講述。577Please respect copyright.ＰＥＮＡＮＡD9uSSTbTFO
延伸閱讀:https://www.penana.com/article/500206577Please respect copyright.ＰＥＮＡＮＡSdXpe4sKnA
577Please respect copyright.ＰＥＮＡＮＡD3cMackTRt
577Please respect copyright.ＰＥＮＡＮＡ9VaKSFcoxu
CAR T cell治療法，就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件，引導它們更有效率殲滅對應的細胞;577Please respect copyright.ＰＥＮＡＮＡZkMHCn5MgV
在這個層面上，亦即是癌細胞。577Please respect copyright.ＰＥＮＡＮＡHyPGPkaNFH
577Please respect copyright.ＰＥＮＡＮＡH0h5GMuUzt
(圖2)2010年，一名39歲女士患上腸癌，久經不同款式化療亦未見成效，故此便嘗試當時候較為新穎的CAR T cell 療法。577Please respect copyright.ＰＥＮＡＮＡ4ns7vRQfxb
577Please respect copyright.ＰＥＮＡＮＡkxSJUoFS54
577Please respect copyright.ＰＥＮＡＮＡR0YSVabQWN
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質，所以其治療的方式便是從她身上取得免疫細胞，再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell，再以將這些CAR T cell注入她體內，盼望這些CAR T cell會殲滅腸癌細胞。577Please respect copyright.ＰＥＮＡＮＡ3bwfLgHEUh
577Please respect copyright.ＰＥＮＡＮＡcwoQvnyra6
577Please respect copyright.ＰＥＮＡＮＡKvA2TQGh9J
(圖3)不幸的是，注入CAR T cell後的15分鐘，她出現呼吸困難等症狀，隨之亦送入ICU作出治療，唯5日後亦與世祥辭。577Please respect copyright.ＰＥＮＡＮＡdJQ48FVubK
577Please respect copyright.ＰＥＮＡＮＡwntXD87d6K
577Please respect copyright.ＰＥＮＡＮＡx5YFOdV39V
最後經驗屍及分析各種數據後，相信是因為肺部含有微量ERBB2蛋白質，在抵達癌細胞位置前，那些CAR T cell率先與持有ERBB2的肺部細胞結合，產生過量的免疫反應，引致肺部器官發炎及衰竭，導致氧氣沒能輸送至各器官位置。577Please respect copyright.ＰＥＮＡＮＡmypRkI5C3H
577Please respect copyright.ＰＥＮＡＮＡsI1YRMPECV
在這手術進行之前，亦有不少針對ERBB2的CAR T cell人體試驗，箇中並沒有發生相同症狀。577Please respect copyright.ＰＥＮＡＮＡRbR5tBrdtQ
577Please respect copyright.ＰＥＮＡＮＡdQrv2ZqhqD
這相信是因為是次手術為了希望能夠順利殲滅癌細胞，其注入的T cell數量被以往實驗過多，因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。577Please respect copyright.ＰＥＮＡＮＡ4MCeUGsssb
577Please respect copyright.ＰＥＮＡＮＡj3CaMlFP3R
無論如何，從這之經驗中可得知，ERBB2顯然並不是一道針對癌細胞的理想對象。577Please respect copyright.ＰＥＮＡＮＡhC8b8rI5KL
577Please respect copyright.ＰＥＮＡＮＡEaZG3UX81S
577Please respect copyright.ＰＥＮＡＮＡYkt8Qm8sGs
577Please respect copyright.ＰＥＮＡＮＡzUkysh7Y9D
577Please respect copyright.ＰＥＮＡＮＡ4RkWZcBmsN
577Please respect copyright.ＰＥＮＡＮＡialjH4Ljos
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。577Please respect copyright.ＰＥＮＡＮＡgDdd8ymDnw
577Please respect copyright.ＰＥＮＡＮＡSHWWPKLQfh
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc577Please respect copyright.ＰＥＮＡＮＡwwoWTLu3xd
577Please respect copyright.ＰＥＮＡＮＡBtDqnZgkF9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。577Please respect copyright.ＰＥＮＡＮＡfW6ixo96QL
577Please respect copyright.ＰＥＮＡＮＡAD3mT1Pzqj
Link:577Please respect copyright.ＰＥＮＡＮＡuzo7T3Juui
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio577Please respect copyright.ＰＥＮＡＮＡzpMLDGU5IH
577Please respect copyright.ＰＥＮＡＮＡVgQwMLukbZ
577Please respect copyright.ＰＥＮＡＮＡTWjAS2UbIT
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。577Please respect copyright.ＰＥＮＡＮＡO7cHUqUBnN
577Please respect copyright.ＰＥＮＡＮＡ8PDeCEjQyv
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
577Please respect copyright.ＰＥＮＡＮＡdwvM78hxzz
