減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1053Please respect copyright.ＰＥＮＡＮＡNe5ZWpmc6T
1053Please respect copyright.ＰＥＮＡＮＡphWHTEqm0g
1053Please respect copyright.ＰＥＮＡＮＡ27DArjfykw
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1053Please respect copyright.ＰＥＮＡＮＡb2VnpYEouS
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1053Please respect copyright.ＰＥＮＡＮＡJ0hG28HCQO
1053Please respect copyright.ＰＥＮＡＮＡ40FgGataRE
1053Please respect copyright.ＰＥＮＡＮＡFgYBtCzaEX
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1053Please respect copyright.ＰＥＮＡＮＡLsIwURzBZp
1053Please respect copyright.ＰＥＮＡＮＡOCcYVuasQb
1053Please respect copyright.ＰＥＮＡＮＡH358lQgh9j
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1053Please respect copyright.ＰＥＮＡＮＡh87wYQqz11
1053Please respect copyright.ＰＥＮＡＮＡ5gJYidC3qQ
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1053Please respect copyright.ＰＥＮＡＮＡHEjA7XH1Al
1053Please respect copyright.ＰＥＮＡＮＡUXlpJutJzP
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1053Please respect copyright.ＰＥＮＡＮＡjgeLcGomVg
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1053Please respect copyright.ＰＥＮＡＮＡc4QeIuF4KB
1053Please respect copyright.ＰＥＮＡＮＡfVIkbY4lQu
1053Please respect copyright.ＰＥＮＡＮＡrlGS8Pnxo1
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1053Please respect copyright.ＰＥＮＡＮＡmaUvXDiZxJ
1053Please respect copyright.ＰＥＮＡＮＡx30ITC4Nwh
1053Please respect copyright.ＰＥＮＡＮＡLXmj74Q5Zl
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1053Please respect copyright.ＰＥＮＡＮＡwQ5rsFjjiZ
1053Please respect copyright.ＰＥＮＡＮＡvXF7FEa9MK
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1053Please respect copyright.ＰＥＮＡＮＡlLdY5JlJzg
1053Please respect copyright.ＰＥＮＡＮＡUo9h9aJPHt
1053Please respect copyright.ＰＥＮＡＮＡ7GEDMWVeaj
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1053Please respect copyright.ＰＥＮＡＮＡFhRUOIZQxO
1053Please respect copyright.ＰＥＮＡＮＡayBUptEIec
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1053Please respect copyright.ＰＥＮＡＮＡmIkCdk2hXd
1053Please respect copyright.ＰＥＮＡＮＡTxDQjrjTqQ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1053Please respect copyright.ＰＥＮＡＮＡhxImLNMJI3
1053Please respect copyright.ＰＥＮＡＮＡkdaNdrHPh9
Link:1053Please respect copyright.ＰＥＮＡＮＡLoo0wPVl8x
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1053Please respect copyright.ＰＥＮＡＮＡRrhJ4RXC1p
1053Please respect copyright.ＰＥＮＡＮＡn9qnyXt6Jc
1053Please respect copyright.ＰＥＮＡＮＡJWMmbmDgQ6
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1053Please respect copyright.ＰＥＮＡＮＡleLytsIo6i
1053Please respect copyright.ＰＥＮＡＮＡIt398jSPmg
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1053Please respect copyright.ＰＥＮＡＮＡYhFny1HisV
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661053Please respect copyright.ＰＥＮＡＮＡx0X9f24fMf
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1053Please respect copyright.ＰＥＮＡＮＡuzo7CBdmnB
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1053Please respect copyright.ＰＥＮＡＮＡkXWaw3hEwP
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1053Please respect copyright.ＰＥＮＡＮＡUOs5bSBmEN
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
