癌症一直是備受關注的議題，至今已累積不少證據，癌細胞的新陳代謝與普通細胞有著與別不同的地方。983Please respect copyright.ＰＥＮＡＮＡGNMfUrCq5J
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不少科學家深信，若然能夠針對癌細胞獨有的新陳代謝機制，將能更有效及針對性抑壓癌細胞的生長，甚至是殲滅它們。983Please respect copyright.ＰＥＮＡＮＡyuRTmQwKWv
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近日，有科學家發表文章（Ref1)，提出新的證據顯示新陳代謝對於癌細胞擴展的重要性。983Please respect copyright.ＰＥＮＡＮＡwZVb33uAMw
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圖1）講解文章內容之前，我們需要快速學習一下相關的術語。983Please respect copyright.ＰＥＮＡＮＡqiqyXyB5uT
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腫瘤由原來的位置轉移到另外一個器官，整個過程我們稱之為Metastasis。983Please respect copyright.ＰＥＮＡＮＡTnOrj8TVu5
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Primary Tumor(原發腫瘤)就是指原本被發現的癌細胞所在地，癌細胞會透過血液循環系統(Blood Circulatory System)或者淋巴系統(Lymphatic System)而從原本的位置轉移到另外一個器官，若然癌細胞能夠在第二個器官順利安頓下來及繁殖生長的話，我們會稱那腫瘤為Secondary Tumor（繼發性腫瘤）。983Please respect copyright.ＰＥＮＡＮＡq7WqT6eClP
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非常遺憾地，很多癌症病人的死因就在於Metastasis的發生，亦即是繼發性腫瘤的出現。983Please respect copyright.ＰＥＮＡＮＡ4Su3oLVTKj
所以現今有不少科學家致力研究癌細胞Metastasis的機制，希望可以找出有效的方法阻止其發生。983Please respect copyright.ＰＥＮＡＮＡc3g4Cbl5t4
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（圖2）科學家們分別從30歲以下人士及60歲以上人士抽取其血清用作培養癌細胞之用。983Please respect copyright.ＰＥＮＡＮＡKeioNEDUnZ
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他們發現，利用60歲以上人士血清培養過的癌細胞，將比30歲以下人士的983Please respect copyright.ＰＥＮＡＮＡ9PFBfk9sLF
1.更呈化療藥物抗藥性983Please respect copyright.ＰＥＮＡＮＡtBL5P9PgeO
2.更容易使癌細胞出現Metastasis983Please respect copyright.ＰＥＮＡＮＡjCK4SrPnSN
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（圖3）經過一大輪的實驗後，科學家們發現60歲以上人士的血清含有更多methylmalonic acid (MMA)。983Please respect copyright.ＰＥＮＡＮＡaKHuzfiP1a
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當清除血清裡的MMA過後，血清亦因而失去誘導癌細胞發生Metastasis的功能；983Please respect copyright.ＰＥＮＡＮＡeA1MT1trpU
MMA的來源，已知是由代謝蛋白質及脂肪的時候會產生出來。983Please respect copyright.ＰＥＮＡＮＡl9GZu1i0cb
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而他們亦證實，脂肪結構會協助MMA更有效率進入癌細胞，誘發一系列的過程誘使Metastasis發生。983Please respect copyright.ＰＥＮＡＮＡBJ89r8IeWV
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確實究竟是甚麼的脂肪結構，以及為何年老人士會有較多的MMA，暫時還沒能搞清楚。983Please respect copyright.ＰＥＮＡＮＡ2LL7eiCMRX
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缺乏維他命B12，已被確定為會引致更多MMA的產生，但是從60歲以上人士的血清裡頭並沒有發現維他命B12與血清的MMA有直接的關聯，相信一定是有其他的原因導致MMA濃度的增加。983Please respect copyright.ＰＥＮＡＮＡf3DEnq8VwI
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要注意的是，文章所說的是，MMA有著誘導癌細胞進行Metastasis功效，而不是指MMA能夠誘導細胞轉化成為癌細胞。983Please respect copyright.ＰＥＮＡＮＡU3yTTky9cC
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總結來說，隨著歲數的增加，我們身體裡的MMA濃度亦會增加，提供了一個「良好」的環境讓癌細胞進行Metastasis。983Please respect copyright.ＰＥＮＡＮＡsenPzyvPmi
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無論如何，如何想利用這結果來進一步發展日後的癌細胞醫療方法，還需要深入搞清楚裡頭的機制才行。983Please respect copyright.ＰＥＮＡＮＡaPWYBXFVoJ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。983Please respect copyright.ＰＥＮＡＮＡ3oPOQYB54k
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc983Please respect copyright.ＰＥＮＡＮＡtmhLPnsv3Q
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。983Please respect copyright.ＰＥＮＡＮＡ5VJHUCOkmR
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Link:983Please respect copyright.ＰＥＮＡＮＡuALONepFDh
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio983Please respect copyright.ＰＥＮＡＮＡv5P3qkgr8k
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有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。983Please respect copyright.ＰＥＮＡＮＡKfevosEAHL
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Ref1:https://www.nature.com/articles/s41586-020-2630-0
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