皮膚受傷的時候,大多數的情況下都會出現結焦情況,過一段時間後傷口便會縫合。759Please respect copyright.PENANADaTMA6EtuZ759Please respect copyright.PENANAX4zYnaVC8J
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有時候,皮膚會留有疤痕,但又有一些情況下會不留痕跡般似的進行修復,就像沒有事發生過一樣。759Please respect copyright.PENANAwX3IGZ5MTb
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究竟最終會否留有疤痕,是看幸運還是甚麼呢?759Please respect copyright.PENANAO1bz9abC6n
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(圖2)近日,有科學家發表文章(Ref1),對此作出了一個頗為完滿的解答。759Please respect copyright.PENANAApi2oflSIv759Please respect copyright.PENANA79YiwaqM8Z
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他們在老鼠耳仔上開一個細洞,然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後,傷口會完美修復不留疤。759Please respect copyright.PENANAAOpfcrCjVq
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而在缺乏TRPA1神經細胞的老鼠,就算塗上(IMQ),傷口始終會留有疤痕,表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。759Please respect copyright.PENANALTVBhNmFb5
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(圖3)他們進行了一系列的實驗,最終找出了箇中機制,以下為最簡化版本。759Please respect copyright.PENANAcjzGHTL4ou759Please respect copyright.PENANAkhX3xLczhz
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1.傷口塗上IMQ後,將會引起發炎作用。759Please respect copyright.PENANAA1vn3wrrzL
2.發炎作用刺激TRPA1神經細胞。759Please respect copyright.PENANAk5JpyR0HTV
3.免疫系統細胞(dermal dendritic cells、γδ T cells)被傳召前來。759Please respect copyright.PENANAoXsvVpPjZe
4.免疫系統細胞釋出相關物質(Interlunkin17、22、23)。759Please respect copyright.PENANApAD2LmL2qw
5.一系列的過程發生過後,肌膚完美修復。759Please respect copyright.PENANAdyPajvXadc
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此研究的結果針對於老鼠的皮膚癒合情況,未必能套用在人類身上,需要作出人體試驗才能廣泛證實此結果。759Please respect copyright.PENANAlAPc1AIJCh
另外,IMQ的塗用時機還需要進一步確認,何時觸發發炎作用才是適當的時機還需要一系列的測試。759Please respect copyright.PENANA15nZ9UreN7
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不過有一點非常重要的是,當人類皮膚受傷的時候,自身是不會主動觸動TRPA1神經細胞。759Please respect copyright.PENANA8vsOvg5jmJ
若然整個結果能套用在人類身上的話,那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞,觸發一系列的過程使傷口以不留疤痕的方式完美癒合!759Please respect copyright.PENANAvT8FnXtE7X
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。759Please respect copyright.PENANAiIrSNwXntf
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc759Please respect copyright.PENANAQxs5k9Tzd5
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。759Please respect copyright.PENANAz0nEbR4Mdm
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Link:759Please respect copyright.PENANA7fzwPCqqJM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio759Please respect copyright.PENANA7pHpb28DhW
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最後亦請幫一幫忙簽署袁爸的白宮呈請,幫忙為香港出一份力。759Please respect copyright.PENANAhSge7RHSLe
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now759Please respect copyright.PENANANyRFVcge51
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。759Please respect copyright.PENANAZyFZyoCIkD
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Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683
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