科普專欄–薯不揀單 - 深入淺出–建構人造腸道厚膜的藥物

腸道是人體吸收葡萄糖的主要地方，亦是消化乳糖酵素(Lactase）的聚居地。139Please respect copyright.ＰＥＮＡＮＡwpePv3ChAH
缺乏Lactase的人並不建議進食含有乳糖的產品，否則會釀起肚痾、腹痛、作嘔等症狀，學名為Lactose Intolerance。139Please respect copyright.ＰＥＮＡＮＡ2Cr8w5NEJm
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同時，腸道亦是寄生蟲的蝸居，飲用不乾淨水的話有機會讓血吸蟲寄生在腸道之中，引起血吸蟲病（Schistosomiasis)，為全球第二大僅次於瘧疾(Malaria)的寄生蟲病。139Please respect copyright.ＰＥＮＡＮＡ02IzaZCAPA
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（圖2）近日，有科學家發表文章（Ref1)，他們研發出一款口服藥物，主要利用豬隻作為動物模型，證實豬隻吞下藥物後的12分鐘會腸道形成厚膜。139Please respect copyright.ＰＥＮＡＮＡOfVd1HOVRN
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此厚膜不會在其他器官上形成，而在24小時後厚膜亦會自然脫落，排出體外。139Please respect copyright.ＰＥＮＡＮＡC65lcny3yD
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（圖3）根據口服藥物的配方不同，厚膜的特性亦能隨之轉變。139Please respect copyright.ＰＥＮＡＮＡ9f1ApsBwof
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厚膜可配載消化乳糖酵素(Lactase)，對比沒有厚膜，能增強20倍酵素的能力，可消除Lactose Intolerance的問題。139Please respect copyright.ＰＥＮＡＮＡOHtNSmYlOf
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而增強厚膜密度的話，亦可減少腸道吸收葡萄糖七成能力，這特點尤其受益於糖尿病人，能大幅度阻上血糖飄升。139Please respect copyright.ＰＥＮＡＮＡgPEJTsU2OS
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另外，厚膜亦可配載殺寄生蟲藥(Praziquantel)，增加藥物滯留在腸道的時間，更有效率殺滅寄生蟲。139Please respect copyright.ＰＥＮＡＮＡzwF5FdbnC5
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（圖4）最為振奮的是，此方法在人類腸道組織亦見效，而且藥物對各種實驗室人體細胞亦無呈現有害效果。139Please respect copyright.ＰＥＮＡＮＡHdIBrsBFj5
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老鼠服用藥物28日後，體重血壓等一切正常。139Please respect copyright.ＰＥＮＡＮＡJYjllFwwze
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若然此藥物能進一步在人類進行試驗的話，確立藥物運作正常及不會帶來任何副作用或安全問題的話，絕對大有潛質會成為治理糖尿病的新一代藥物。139Please respect copyright.ＰＥＮＡＮＡskfA9kOJAr
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc139Please respect copyright.ＰＥＮＡＮＡOa4OQ323co
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。139Please respect copyright.ＰＥＮＡＮＡXOc58CTRqq
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Ref1:https://stm.sciencemag.org/content/12/558/eabc0441copyright protection135ＰＥＮＡＮＡXxMvZIIXA0