肌肉大概佔據身體重量的40%。530Please respect copyright.PENANA5nwt66tRZi530Please respect copyright.PENANAxzI5QXVzfZ
530Please respect copyright.PENANAsKbXoVdy0d
踏入50歲後,平均每10年就會有15-30%的肌肉流失。530Please respect copyright.PENANAm2Pu4z2nUV
530Please respect copyright.PENANAtbhANYX32Z
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。530Please respect copyright.PENANA54EQJVOkSx530Please respect copyright.PENANAmpd4nb3drR
530Please respect copyright.PENANAdWijFvSaEg
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。530Please respect copyright.PENANAbpHUrbnNPt
530Please respect copyright.PENANAXEZOPGoIat
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。530Please respect copyright.PENANAky9OR9txgC
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。530Please respect copyright.PENANA9xfSgoOWa8530Please respect copyright.PENANAD1J3x1WTWn
530Please respect copyright.PENANAQiWbRIN1IH
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。530Please respect copyright.PENANAufTmKdYWCL
530Please respect copyright.PENANA1QrwXUJUEn
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。530Please respect copyright.PENANAqJUk1D7eeC
530Please respect copyright.PENANA2CIONDKlmK
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。530Please respect copyright.PENANAu0Cw4I6OXZ
530Please respect copyright.PENANAWN1Be0hwEb
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。530Please respect copyright.PENANAnOP4BBn40L
530Please respect copyright.PENANAmVUns7HDPc
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。530Please respect copyright.PENANAWxQ2kVQbgy
530Please respect copyright.PENANAfHuU6ixnHj
530Please respect copyright.PENANA2HB1RtEsdd
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。530Please respect copyright.PENANAzjeSLhXx6w
530Please respect copyright.PENANAytwOoJDDt4
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc530Please respect copyright.PENANAgxK7Ntk5aV
530Please respect copyright.PENANAQGqI2BdZmz
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。530Please respect copyright.PENANAXIogWEC94F
530Please respect copyright.PENANAfQ6lGXJZXp
Link:530Please respect copyright.PENANAgSCrZ8VS19
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio530Please respect copyright.PENANAR9bgBWcnZI
530Please respect copyright.PENANAmFdxxo81t1
530Please respect copyright.PENANA6k78n82Hfx
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。530Please respect copyright.PENANA8N8jxXxH7a
530Please respect copyright.PENANAEW7zayc2uo
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059530Please respect copyright.PENANAuD8kpW1Dw0