不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。324Please respect copyright.PENANABhaCpF4dB0
324Please respect copyright.PENANAzwOg74nZFW
324Please respect copyright.PENANAFKcPRj2qzQ
與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。324Please respect copyright.PENANAVQ3CCawmYD
324Please respect copyright.PENANAIyOyMsyJdO
(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。324Please respect copyright.PENANAqnXpx5K15g
324Please respect copyright.PENANA8dZwfpiyw3
324Please respect copyright.PENANABWAyGClaHg
324Please respect copyright.PENANAJqdD7bQEiW
(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。324Please respect copyright.PENANAef7CZ9wYpE
324Please respect copyright.PENANADahlSkXMOL
324Please respect copyright.PENANAEmidjgypmP
PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。324Please respect copyright.PENANAHetn3L6zaX
324Please respect copyright.PENANAz43A5Dawyy
只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。324Please respect copyright.PENANAfK6zrdrrom
324Please respect copyright.PENANAOEKH7faze5
這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。324Please respect copyright.PENANAHxL3bMjI3O
324Please respect copyright.PENANApmMJtFqfUx
324Please respect copyright.PENANAgtzKg4ROn0
癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。324Please respect copyright.PENANASxaxwtwNq6
324Please respect copyright.PENANAarAYyYTnhj
因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。324Please respect copyright.PENANAufxlGOOOMV
324Please respect copyright.PENANA4SvhZEebIX
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。324Please respect copyright.PENANAxh7n8KX98U
324Please respect copyright.PENANAIFBxH8x1SC
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc324Please respect copyright.PENANAEqWcZctm9v
324Please respect copyright.PENANA4rVOFl0iZP
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。324Please respect copyright.PENANASXhDLorTSn
324Please respect copyright.PENANAiUHlPSlc5r
Link:324Please respect copyright.PENANAM1mf9s7GfH
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio324Please respect copyright.PENANAuownc6WxNq
324Please respect copyright.PENANA8ZoMRJT8H9
324Please respect copyright.PENANATxOmtA1yBH
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。324Please respect copyright.PENANA2ljTt1lPgH
324Please respect copyright.PENANArigHk9DXHq
Ref1:https://www.nature.com/articles/nature13528324Please respect copyright.PENANAglVjsy8i7T