世界非常殘酷，美味可口的食物很多時候都是高脂高卡路里。965Please respect copyright.ＰＥＮＡＮＡmhELC2WOUg
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如果餐單的卡路里長期是以脂肪為主導的話，又是否會更容易產生癌症呢?965Please respect copyright.ＰＥＮＡＮＡjezH3X8dT3
965Please respect copyright.ＰＥＮＡＮＡvVr3gqILRV
（圖2）有科學家對此進行研究（Ref1)，餵食老鼠為期7日脂肪佔總卡路里約60%的餐單，然後再透過血管移植人類的口腔癌細胞，其後密切跟進腫瘤的狀況。965Please respect copyright.ＰＥＮＡＮＡiNvxAYHdN9
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如何跟進? 就是用上集所介紹的螢光技術。965Please respect copyright.ＰＥＮＡＮＡejFHKYzUel
965Please respect copyright.ＰＥＮＡＮＡod27wIUUPp
詳情可見：三十秒科學–透視癌細胞965Please respect copyright.ＰＥＮＡＮＡRYpea3Jw43
- 分享自 LIHKG 討論區965Please respect copyright.ＰＥＮＡＮＡ10atGfJNb6
https://lih.kg/2408323965Please respect copyright.ＰＥＮＡＮＡsnBFnGIM9u
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（圖3）從圖中可以看得見，進食脂肪主導餐單的老鼠，原生腫瘤的體積不但更為巨大，而且亦有更高機率出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡzM42FsKC3L
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965Please respect copyright.ＰＥＮＡＮＡEnkHXpOPNT
CD36是輔助細胞吸取脂肪酸的蛋白質，當癌細胞的CD36被除去的時候，莫論餐單是否由脂肪主導，原生腫瘤的體積均沒有顯著大變化，而且亦沒有出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡqoxcbXLndC
965Please respect copyright.ＰＥＮＡＮＡizY78O1g3u
（圖4）當細胞遇上棕櫚酸約兩日後，細胞的CD36蛋白質數量亦會因而上升 。965Please respect copyright.ＰＥＮＡＮＡyvBS7UdhMR
965Please respect copyright.ＰＥＮＡＮＡhoWJyA8ErQ
965Please respect copyright.ＰＥＮＡＮＡ6NvMieMlLM
從右圖中可以清晰見得到，經過棕櫚酸「調教」過的癌細胞，移植到老鼠後會出現非常明顯的癌細胞轉移過程。965Please respect copyright.ＰＥＮＡＮＡsgX16x8hSb
而當癌細胞的CD36蛋白質被移除後，癌細胞轉移過程亦再沒有發生。965Please respect copyright.ＰＥＮＡＮＡ9yGJBCU3QR
965Please respect copyright.ＰＥＮＡＮＡUr7ZaN4cyM
現時有不少藥物嘗試針對CD36來醫治癌細胞或阻止其進行轉移的程序，但不少藥物均在第二期臨床研究裡頭因為出現副作用或效率未如預期被迫中斷。965Please respect copyright.ＰＥＮＡＮＡUVhc0C4LOk
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或許需要更多研究理解CD36在細胞的作用或機制，才能設計出輕微副作用的治癌藥物。965Please respect copyright.ＰＥＮＡＮＡjhiHPOas7M
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。965Please respect copyright.ＰＥＮＡＮＡvj7PHCeeN8
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc965Please respect copyright.ＰＥＮＡＮＡGOmniR9AhO
965Please respect copyright.ＰＥＮＡＮＡOBidIVm0Sr
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。965Please respect copyright.ＰＥＮＡＮＡTdtTlkdRcp
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Link:965Please respect copyright.ＰＥＮＡＮＡupG33gfKFV
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio965Please respect copyright.ＰＥＮＡＮＡHwPIUnWrr0
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。965Please respect copyright.ＰＥＮＡＮＡORMmX5SfZC
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/965Please respect copyright.ＰＥＮＡＮＡ7GE6iw0g0Z
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