黃金葡萄球菌這字眼，周不時亦會在新聞媒體聽得到。737Please respect copyright.ＰＥＮＡＮＡRUDc4DDOSl
737Please respect copyright.ＰＥＮＡＮＡSOBLcbwMIn
737Please respect copyright.ＰＥＮＡＮＡe8YuEWmffT
它之所以被冠以黃金這稱號，是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin)，以及微量黃色化合物4,4‘-Diaponeurosporene。737Please respect copyright.ＰＥＮＡＮＡolVkAWFnNd
737Please respect copyright.ＰＥＮＡＮＡd6HcJPWxpp
（圖2）當細菌入侵腸道的時候，我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species)，對細菌進行攻擊。737Please respect copyright.ＰＥＮＡＮＡoqTfQEh3fR
737Please respect copyright.ＰＥＮＡＮＡGuzgpOYiLq
737Please respect copyright.ＰＥＮＡＮＡ84uvBYcBBB
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素，因此免疫系統所產生的游離基攻擊對它傷害不大。737Please respect copyright.ＰＥＮＡＮＡK618OBG6sx
737Please respect copyright.ＰＥＮＡＮＡ9qhpyClrd0
然而，如果刪去製作色素的蛋白酶，「黃金」葡萄球菌失去抵擋游離基的手段，對宿主的感染力亦因而大大減低。737Please respect copyright.ＰＥＮＡＮＡLDVS2qZLKa
737Please respect copyright.ＰＥＮＡＮＡcKTfoJKkiS
（圖3）同時間，若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌，獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強，引證色素對於細菌感染力的重要性。737Please respect copyright.ＰＥＮＡＮＡAwldcj6Kiv
737Please respect copyright.ＰＥＮＡＮＡeopo8De5br
737Please respect copyright.ＰＥＮＡＮＡBeVZb4iHhe
（圖4）再舉另外一道例子，Cryptococcus neoformans是一種真菌(fungus)，737Please respect copyright.ＰＥＮＡＮＡ3wqzde2R9h
它能夠製作黑色素(Melanin)，亦即是上集所談及決定髮膚眼色的色素。737Please respect copyright.ＰＥＮＡＮＡW72Yx5uf64
737Please respect copyright.ＰＥＮＡＮＡ0wSBqqb824
737Please respect copyright.ＰＥＮＡＮＡbnK70lJ4H1
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外，其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合，大大削弱藥物傷害真菌的能力。737Please respect copyright.ＰＥＮＡＮＡu5j3Yd5Upa
737Please respect copyright.ＰＥＮＡＮＡMdXWFB04eg
737Please respect copyright.ＰＥＮＡＮＡ3WGYDxnWLi
延伸閱讀:737Please respect copyright.ＰＥＮＡＮＡEPqw1dlS9j
深入淺出–從深海生物中發掘出抗真菌藥物737Please respect copyright.ＰＥＮＡＮＡkaUincEuBz
- 分享自 LIHKG 討論區737Please respect copyright.ＰＥＮＡＮＡY5gebfgVgb
https://lih.kg/2296185737Please respect copyright.ＰＥＮＡＮＡVB5mlHc9xW
737Please respect copyright.ＰＥＮＡＮＡHN3fRvlC9X
737Please respect copyright.ＰＥＮＡＮＡ3V5yu8CZCj
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。737Please respect copyright.ＰＥＮＡＮＡCFt0VpNg66
737Please respect copyright.ＰＥＮＡＮＡNXNhAZ1oKO
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc737Please respect copyright.ＰＥＮＡＮＡE0Z7y45vA0
737Please respect copyright.ＰＥＮＡＮＡjmQNnyxgfT
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。737Please respect copyright.ＰＥＮＡＮＡ9oNpgPmhXc
737Please respect copyright.ＰＥＮＡＮＡFihlTX4xfD
Link:737Please respect copyright.ＰＥＮＡＮＡPy3TGS6BMK
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio737Please respect copyright.ＰＥＮＡＮＡAv2GxcBNBg
737Please respect copyright.ＰＥＮＡＮＡ2IL8piv1R3
737Please respect copyright.ＰＥＮＡＮＡlnU2fl9J7O
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。737Please respect copyright.ＰＥＮＡＮＡMyjHvojXnf
737Please respect copyright.ＰＥＮＡＮＡkvKQvEDdrf
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/737Please respect copyright.ＰＥＮＡＮＡHnLf8Ccfy7
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
