上集略述了心臟肥大與心臟衰竭的關連，今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。572Please respect copyright.ＰＥＮＡＮＡ1hV0tNz6vv
572Please respect copyright.ＰＥＮＡＮＡSAxhf2OPX2
572Please respect copyright.ＰＥＮＡＮＡdSLACv38Sg
上集:https://lih.kg/gOrCdS572Please respect copyright.ＰＥＮＡＮＡyrdHsxRKiU
572Please respect copyright.ＰＥＮＡＮＡqLbPIJN4hk
(圖2)研究發現，當利用縫線手法引致心臟處於肥大狀態的時候，一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。572Please respect copyright.ＰＥＮＡＮＡQs4xtwqezh
572Please respect copyright.ＰＥＮＡＮＡ1l7Tz6MPqu
572Please respect copyright.ＰＥＮＡＮＡjipm1Oj4nl
572Please respect copyright.ＰＥＮＡＮＡ5d94i3ydu0
(圖3)當GRK5進入細胞核後，它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動，因而改變其自身的形狀，發揮一系列的功效引致心臟肥大。572Please respect copyright.ＰＥＮＡＮＡ4q9lsomYcV
572Please respect copyright.ＰＥＮＡＮＡsDmQaY0bTk
572Please respect copyright.ＰＥＮＡＮＡ0viLAUhFbk
見狀，科學家便特意單獨注入其紅色部份到細胞核，目的就是想透過紅色部份的霸佔，阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動，使其功效喪失。572Please respect copyright.ＰＥＮＡＮＡhABIfGUack
572Please respect copyright.ＰＥＮＡＮＡpY2eGth8H8
形象化來說，就是某勢力派人霸佔旁聽座位，讓其他人士無法入座。572Please respect copyright.ＰＥＮＡＮＡqjstNZ3tsS
572Please respect copyright.ＰＥＮＡＮＡB6XoyL2adW
572Please respect copyright.ＰＥＮＡＮＡm6XXhiAcro
(圖4)縫線後所引起的心臟肥大，並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。572Please respect copyright.ＰＥＮＡＮＡhqYxHmJHR8
572Please respect copyright.ＰＥＮＡＮＡBlBhcWJ5sH
572Please respect copyright.ＰＥＮＡＮＡH8r3QN4GKd
最為重要的是，心臟肥大所引起的心肌纖維化(藍色箭嘴)，並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。572Please respect copyright.ＰＥＮＡＮＡu7LWhujZK9
572Please respect copyright.ＰＥＮＡＮＡUL3xGSNV7i
572Please respect copyright.ＰＥＮＡＮＡKxqKaq5dMY
換句話說，這GRK5的紅色部份，非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。572Please respect copyright.ＰＥＮＡＮＡpLmr8YJy1B
572Please respect copyright.ＰＥＮＡＮＡRdnXEFhn01
572Please respect copyright.ＰＥＮＡＮＡWDHljORnjY
572Please respect copyright.ＰＥＮＡＮＡwxSlnXR5Py
572Please respect copyright.ＰＥＮＡＮＡoItGuhi3YN
572Please respect copyright.ＰＥＮＡＮＡyFjPNxCrdt
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。572Please respect copyright.ＰＥＮＡＮＡJYVISXSd56
572Please respect copyright.ＰＥＮＡＮＡ5DYLrC9uLS
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc572Please respect copyright.ＰＥＮＡＮＡHsljwvqJY1
572Please respect copyright.ＰＥＮＡＮＡ014hVnhQWd
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。572Please respect copyright.ＰＥＮＡＮＡzIL7ek7HdN
572Please respect copyright.ＰＥＮＡＮＡV5CbwwMMNA
Link:572Please respect copyright.ＰＥＮＡＮＡQeQmsfAEbA
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio572Please respect copyright.ＰＥＮＡＮＡ2nfchvl3XO
572Please respect copyright.ＰＥＮＡＮＡsRoKgvvvq3
572Please respect copyright.ＰＥＮＡＮＡ8mCRicRMow
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。572Please respect copyright.ＰＥＮＡＮＡLnrGfqGSaN
572Please respect copyright.ＰＥＮＡＮＡE9fkajoxFL
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968572Please respect copyright.ＰＥＮＡＮＡojNhxK71FZ
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
