癌細胞跟正常細胞一樣,就算處於停止生長的狀態,均需攝取營養維持細胞運作。249Please respect copyright.PENANA3RXFngZfbT
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在這個基礎下,有不少主張提倡以生酮飲食(Ketogenic Diet)作為醫治癌症的輔助療法。249Please respect copyright.PENANAggTD07Yz1j
究竟這是「武肺乃由5G網路而起」之流,還是有其實質科學實據支持呢?249Please respect copyright.PENANABvevsxzouv
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(圖2)有不少的癌細胞均出現與PI3K蛋白質有關的變異,促使到它們具備更強大的快速繁殖及抵禦進行自我滅亡機制特性。249Please respect copyright.PENANAYxKtuOxkB1
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有見及此,科學家們攜手合作,研發出藥物針對已變異的PI3K蛋白質,並在2010年其間進行大量的人類臨床研究,對相應的癌症病人下藥。249Please respect copyright.PENANAbDjshktaNa
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遺憾的是,結果非常參差,整體成效並不理想。249Please respect copyright.PENANAZUvJ3ckIal
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(圖3)深入探討為何會失敗後,科學家發現藥物對人體產生了一道副作用,就是誘使肝臟產生糖份,使血糖上升。249Please respect copyright.PENANAkAbecOO0EZ
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胰臟因著血糖的上升而產生胰島素,而非常諷刺的是,胰島素是激勵PI3K蛋白質的物質。249Please respect copyright.PENANAeOGjzAyfkd
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亦即是說,藥物副作用所產生的胰島素,抵消了藥物本來抑制PI3K的功用。249Please respect copyright.PENANAR8cHT7hgpp
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(圖4)基於生酮飲食能夠消耗肝臟的糖原,以及維持血液低胰島素水平,科學家嘗試利用生酮飲食來制衡藥物的副作用,並在老鼠模型上取得非常可觀的成果。249Please respect copyright.PENANAz2HdHH8N2O
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現在即將進行子宮內壁膜癌症患者的臨床測試,以生酮飲食再配上PI3K藥物,希望能夠取得理想的成果。249Please respect copyright.PENANAQPlYaWBDmt
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但有一點要注意的是,在某類型血癌及腦癌個案,生酮飲食反之然會鼓吹癌細胞加速生長,這很有可能是因為是某類別的癌細胞特別傾向吸收脂肪或酮體。249Please respect copyright.PENANAmZ8Bia82fN
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換句話說,在尚未摸透自身所患的癌細胞其新陳代謝特性之前,胡亂採取生酮飲食將有機會引來反效果,間接為癌細胞提供有利生長的環境。249Please respect copyright.PENANAAk4wT8AIlV
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Ref1:https://www.nature.com/articles/s41586-018-0343-4249Please respect copyright.PENANApSTKzZWOyS
Ref2:https://science.sciencemag.org/content/372/6537/20249Please respect copyright.PENANAbvN3WT8h6o