癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。519Please respect copyright.ＰＥＮＡＮＡUSw6o92Rtj
519Please respect copyright.ＰＥＮＡＮＡKlYYNE68ID
519Please respect copyright.ＰＥＮＡＮＡQMWQRgI9QF
「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。519Please respect copyright.ＰＥＮＡＮＡsGOlVO7iHL
519Please respect copyright.ＰＥＮＡＮＡ83dDWIWksm
(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。519Please respect copyright.ＰＥＮＡＮＡYmG1p9iwzU
519Please respect copyright.ＰＥＮＡＮＡVuxUEPUjzB
519Please respect copyright.ＰＥＮＡＮＡ1fsHA5iM47
早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。519Please respect copyright.ＰＥＮＡＮＡGeqCbh73xY
519Please respect copyright.ＰＥＮＡＮＡyk0Vaw978k
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。519Please respect copyright.ＰＥＮＡＮＡJ51Y6grGHj
519Please respect copyright.ＰＥＮＡＮＡ7GHNRrm4ZW
519Please respect copyright.ＰＥＮＡＮＡ9Cqn3yARdq
但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。519Please respect copyright.ＰＥＮＡＮＡ9KO429qDBH
519Please respect copyright.ＰＥＮＡＮＡ1nRM0miEaP
有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。519Please respect copyright.ＰＥＮＡＮＡCq0qjXywwA
519Please respect copyright.ＰＥＮＡＮＡgh5oa6fykZ
519Please respect copyright.ＰＥＮＡＮＡcCM1J5EzkA
(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。519Please respect copyright.ＰＥＮＡＮＡcxONg3y9oz
519Please respect copyright.ＰＥＮＡＮＡDG4JRbhlkm
519Please respect copyright.ＰＥＮＡＮＡ9CcQ86Mo0M
觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。519Please respect copyright.ＰＥＮＡＮＡ1prW45SwOg
519Please respect copyright.ＰＥＮＡＮＡMWeMozSobr
519Please respect copyright.ＰＥＮＡＮＡlsEwHPNCNg
519Please respect copyright.ＰＥＮＡＮＡbimaSfysUv
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。519Please respect copyright.ＰＥＮＡＮＡzYXJiniZsR
519Please respect copyright.ＰＥＮＡＮＡmYBm5ss5wS
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。519Please respect copyright.ＰＥＮＡＮＡuC8L8NBJxy
519Please respect copyright.ＰＥＮＡＮＡmzMkL1Unno
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc519Please respect copyright.ＰＥＮＡＮＡPfs3JmDLU6
519Please respect copyright.ＰＥＮＡＮＡSyw2IY4n7y
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。519Please respect copyright.ＰＥＮＡＮＡ1TxGDbd37N
519Please respect copyright.ＰＥＮＡＮＡFnajw0Qhi0
Link:519Please respect copyright.ＰＥＮＡＮＡrZs4mqunHC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio519Please respect copyright.ＰＥＮＡＮＡUQQZvucIhu
519Please respect copyright.ＰＥＮＡＮＡEUpPb6y7ci
519Please respect copyright.ＰＥＮＡＮＡ3ZXL0fHGlS
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。519Please respect copyright.ＰＥＮＡＮＡaGqJkZMX6p
519Please respect copyright.ＰＥＮＡＮＡYGYP0jyhE9
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/519Please respect copyright.ＰＥＮＡＮＡUJi43x6zyL
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
