我們身體的各部份均是由細胞組成，眼睛晶片也自當然不例外。834Please respect copyright.ＰＥＮＡＮＡPoPKq8xzcZ
但細胞裡頭有著各式各樣的細胞器官，例如負責製造能源的粒線體(mitochondria)、收藏DNA的細胞核(nucleus)等，它們顯然並不是透明的。834Please respect copyright.ＰＥＮＡＮＡ8HyDTGYps4
834Please respect copyright.ＰＥＮＡＮＡDAIyR1gcF5
究竟身體有甚麼方法可以製造透明且能讓光線通過的眼鏡晶片呢?834Please respect copyright.ＰＥＮＡＮＡ52txiADbMa
834Please respect copyright.ＰＥＮＡＮＡCmqunFEpI1
834Please respect copyright.ＰＥＮＡＮＡtnTqUOwh9h
834Please respect copyright.ＰＥＮＡＮＡhnOHOH7TaI
(圖2)答案很簡單，就是把那些細胞器官通通摧毀。834Please respect copyright.ＰＥＮＡＮＡlSmilvHrEl
834Please respect copyright.ＰＥＮＡＮＡ6JIVIyBqtb
834Please respect copyright.ＰＥＮＡＮＡ74TrumiiqZ
從圖中可見，晶片的外圍有著表皮細胞(Epithelial cells)以及纖維細胞(Fibre cells)，唯獨是中間區域的細胞，它們的細胞器官均接近得消失得一乾二淨。834Please respect copyright.ＰＥＮＡＮＡ9KobQcG5aE
834Please respect copyright.ＰＥＮＡＮＡUzY4QtjFbZ
834Please respect copyright.ＰＥＮＡＮＡw6WAZhDyup
(圖3)有科學家利用班馬魚作動物模型，並將兩款細胞器官分別染成綠色及紅色。834Please respect copyright.ＰＥＮＡＮＡv5RuD1GA04
834Please respect copyright.ＰＥＮＡＮＡ5zL7xXreM5
834Please respect copyright.ＰＥＮＡＮＡCM9Ib5fwzT
從圖中可見，直至班馬魚受精後約59小時左右，綠色及紅色均分別清晰可見及有著其獨特的分佈，表示兩款細胞器官非常健在。834Please respect copyright.ＰＥＮＡＮＡpaF6cUpLb3
但在約60小時打後，紅色和綠色開始有著衰退的現象，亦即表示細胞器官開始逐漸被受摧毀。834Please respect copyright.ＰＥＮＡＮＡU7Dj1uyPsz
834Please respect copyright.ＰＥＮＡＮＡUpzWY3ulU6
834Please respect copyright.ＰＥＮＡＮＡuKBkHPNi4k
(圖4)找出眼睛晶片的細胞器官被受摧毀的時段後，研究人員便著手進行一系列的實驗，834Please respect copyright.ＰＥＮＡＮＡbYjFYVnwP7
並發現名為plaat的蛋白質負責在細胞器官的外膜進行破壞，因而引發細胞器官摧毀的過程。834Please respect copyright.ＰＥＮＡＮＡvvDRR2qBfI
834Please respect copyright.ＰＥＮＡＮＡLaSm1L1jAy
834Please respect copyright.ＰＥＮＡＮＡhmXOXPJhj5
圖中為班馬魚的眼睛晶片，可見因為缺乏plaat蛋白質的緣故，細胞器官沒能完整摧毀，其晶片亦變得相對上混濁及不透光，影像亦較為不清晰。834Please respect copyright.ＰＥＮＡＮＡlQYA8FDyd8
834Please respect copyright.ＰＥＮＡＮＡFHac18oQvM
834Please respect copyright.ＰＥＮＡＮＡz9ytW3HXWW
(圖5)除班馬魚外，研究人員亦有利用老鼠進行實驗。834Please respect copyright.ＰＥＮＡＮＡoIxKSpWocZ
834Please respect copyright.ＰＥＮＡＮＡNZoXL3IzG0
834Please respect copyright.ＰＥＮＡＮＡcLZj3rbqUQ
跟班馬魚一樣，缺乏plaat蛋白質的老鼠眼睛晶片變得混濁及不透光，並影響視線。834Please respect copyright.ＰＥＮＡＮＡp1EEaghbSu
834Please respect copyright.ＰＥＮＡＮＡIsllbwt64S
834Please respect copyright.ＰＥＮＡＮＡ325vvJ3y0b
834Please respect copyright.ＰＥＮＡＮＡD6LX6wIALX
834Please respect copyright.ＰＥＮＡＮＡ3fVxndVYzJ
834Please respect copyright.ＰＥＮＡＮＡZyjQN5v9du
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。834Please respect copyright.ＰＥＮＡＮＡCXH6q7bMNy
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc834Please respect copyright.ＰＥＮＡＮＡAhghjZyy8I
834Please respect copyright.ＰＥＮＡＮＡV9lNtBb5Q5
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。834Please respect copyright.ＰＥＮＡＮＡ3mhD1HOo5B
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Link:834Please respect copyright.ＰＥＮＡＮＡHz5EMTwnpL
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio834Please respect copyright.ＰＥＮＡＮＡ7uT80uA53Q
834Please respect copyright.ＰＥＮＡＮＡy76Cpe17lk
834Please respect copyright.ＰＥＮＡＮＡwxM50iW0rj
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。834Please respect copyright.ＰＥＮＡＮＡiykAXrJB49
834Please respect copyright.ＰＥＮＡＮＡolcur5V2wj
Ref1:https://www.nature.com/articles/s41586-021-03439-w834Please respect copyright.ＰＥＮＡＮＡqceRslEsMM
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