減低食慾從而減少進食,某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。804Please respect copyright.PENANARZRPgMF9VZ
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係,804Please respect copyright.PENANAYwxPDvL1kP
其中之一的目標就是設計出一款能壓抑食慾的藥物,輔助癡肥或糖尿病人的治療。804Please respect copyright.PENANAmYn68NT6a5
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。804Please respect copyright.PENANA9Bn9EJIBMJ
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以非常簡化的角度來說,在飽肚狀態下,含有MC4R蛋白質的神經細胞便會受到刺激,我們的食慾亦會隨之受到壓抑。804Please respect copyright.PENANAdWh9OWTBMn
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相反,在飢餓狀態下,含有MC4R蛋白質的神經細胞便會受到壓抑,我們的食慾亦會隨之而來。804Please respect copyright.PENANAc2dnu0qHAc
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老鼠缺乏MC4R蛋白質的話,體重亦會明顯上升。804Please respect copyright.PENANAouedegi9Qd
而MC4R的蛋白質因基因變異而導致部份功能的喪失,亦能在不少癡肥人士身上記錄得到。804Please respect copyright.PENANADXrVoielYk
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(圖3)刺激MC4R,便能減低食慾,減低食慾,便能減低進食量,有助對抗癡肥。804Please respect copyright.PENANAoC39sNobYz
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用,不得不終止研究及停止發展。804Please respect copyright.PENANAjKXuqfS9GQ
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而好消息的是,最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide,並沒有血壓上升的副作用,在符合對應的條件下可用作體重管理之用。804Please respect copyright.PENANAoQusuxBMmS
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。804Please respect copyright.PENANAJmA7cTDkoL
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc804Please respect copyright.PENANArgA5AAlJor
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。804Please respect copyright.PENANASiwpUq7rVE
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Link:804Please respect copyright.PENANA1FX3hYuYrT
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio804Please respect copyright.PENANAGGD6lf5R2f
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。804Please respect copyright.PENANAWKLAIofqWZ
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/804Please respect copyright.PENANA81q2eRdUVy
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466804Please respect copyright.PENANAjjPqzK4HXZ
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/804Please respect copyright.PENANAg4AmJAFq8v
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/804Please respect copyright.PENANAuFaXx4o12J
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/804Please respect copyright.PENANAPNpa2EWLjG