減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1051Please respect copyright.ＰＥＮＡＮＡa3Xz66moqH
1051Please respect copyright.ＰＥＮＡＮＡxBv3Or5YB3
1051Please respect copyright.ＰＥＮＡＮＡZplHGHGsPA
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1051Please respect copyright.ＰＥＮＡＮＡJdWn0trTgI
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1051Please respect copyright.ＰＥＮＡＮＡaR24Xl07gl
1051Please respect copyright.ＰＥＮＡＮＡb6usYOlpKo
1051Please respect copyright.ＰＥＮＡＮＡUsOK4RqTkA
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1051Please respect copyright.ＰＥＮＡＮＡKyQoMn9ZED
1051Please respect copyright.ＰＥＮＡＮＡGEUnTzbLya
1051Please respect copyright.ＰＥＮＡＮＡyh7JfV9Tqp
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1051Please respect copyright.ＰＥＮＡＮＡQ8bLC0G0rX
1051Please respect copyright.ＰＥＮＡＮＡmkDBjAILNi
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1051Please respect copyright.ＰＥＮＡＮＡ82iRKgLXoE
1051Please respect copyright.ＰＥＮＡＮＡjpQUtNk4NE
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1051Please respect copyright.ＰＥＮＡＮＡN11nzEOgRM
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1051Please respect copyright.ＰＥＮＡＮＡh3BP4UDv3r
1051Please respect copyright.ＰＥＮＡＮＡaORM6t7Qwk
1051Please respect copyright.ＰＥＮＡＮＡZp3gACglO4
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1051Please respect copyright.ＰＥＮＡＮＡZ4fR1zpXzV
1051Please respect copyright.ＰＥＮＡＮＡXsAxnmRev2
1051Please respect copyright.ＰＥＮＡＮＡm4jRleU8Jp
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1051Please respect copyright.ＰＥＮＡＮＡaLfrLhSrPG
1051Please respect copyright.ＰＥＮＡＮＡrTICPwJIEd
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1051Please respect copyright.ＰＥＮＡＮＡy6UtoNv2K7
1051Please respect copyright.ＰＥＮＡＮＡFOdaF1IKOn
1051Please respect copyright.ＰＥＮＡＮＡvv4bnWGhXN
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1051Please respect copyright.ＰＥＮＡＮＡiF19UkLDmd
1051Please respect copyright.ＰＥＮＡＮＡg45PymcBfB
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1051Please respect copyright.ＰＥＮＡＮＡWrKQMVGoCc
1051Please respect copyright.ＰＥＮＡＮＡuAIoNLoMEG
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1051Please respect copyright.ＰＥＮＡＮＡZgPl3ruTGT
1051Please respect copyright.ＰＥＮＡＮＡsZUmPI62Ih
Link:1051Please respect copyright.ＰＥＮＡＮＡWDmeoYZGVH
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1051Please respect copyright.ＰＥＮＡＮＡdZXimrNXuf
1051Please respect copyright.ＰＥＮＡＮＡdmNy75KjCm
1051Please respect copyright.ＰＥＮＡＮＡyk56HvAVpw
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1051Please respect copyright.ＰＥＮＡＮＡmpiSkT9p3d
1051Please respect copyright.ＰＥＮＡＮＡ0uYfYJx6KA
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1051Please respect copyright.ＰＥＮＡＮＡmSJO8x64mC
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661051Please respect copyright.ＰＥＮＡＮＡTGxBMV87KB
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1051Please respect copyright.ＰＥＮＡＮＡFQpHHoJv5P
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1051Please respect copyright.ＰＥＮＡＮＡppwSkP0Bad
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1051Please respect copyright.ＰＥＮＡＮＡaz0JZVYWQd
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
