皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。982Please respect copyright.ＰＥＮＡＮＡouOEKozSQn
982Please respect copyright.ＰＥＮＡＮＡUiKwU6qVOc
982Please respect copyright.ＰＥＮＡＮＡDSYF8BwXKO
有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。982Please respect copyright.ＰＥＮＡＮＡSReGVnG5xM
982Please respect copyright.ＰＥＮＡＮＡ6jeHkK4kyJ
究竟最終會否留有疤痕，是看幸運還是甚麼呢？982Please respect copyright.ＰＥＮＡＮＡQrMVdBbD85
982Please respect copyright.ＰＥＮＡＮＡfJthf548Op
982Please respect copyright.ＰＥＮＡＮＡkNsFLOCBle
（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。982Please respect copyright.ＰＥＮＡＮＡ8TEDPmWUT5
982Please respect copyright.ＰＥＮＡＮＡbmxst8n0Bf
982Please respect copyright.ＰＥＮＡＮＡDiWt8dWLff
他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。982Please respect copyright.ＰＥＮＡＮＡvqj0CmPE3Z
982Please respect copyright.ＰＥＮＡＮＡK1YQtAUTAE
而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。982Please respect copyright.ＰＥＮＡＮＡ1Rq2iua22A
982Please respect copyright.ＰＥＮＡＮＡ0Elj7uMsYu
（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。982Please respect copyright.ＰＥＮＡＮＡFRw318Fkpe
982Please respect copyright.ＰＥＮＡＮＡ2VLO5Rp7PL
982Please respect copyright.ＰＥＮＡＮＡyzrL0594dg
1.傷口塗上IMQ後，將會引起發炎作用。982Please respect copyright.ＰＥＮＡＮＡsMtcZPgtle
2.發炎作用刺激TRPA1神經細胞。982Please respect copyright.ＰＥＮＡＮＡryhVNnwoOs
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。982Please respect copyright.ＰＥＮＡＮＡfWhJq25Wo0
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。982Please respect copyright.ＰＥＮＡＮＡiyagOpvW1i
5.一系列的過程發生過後，肌膚完美修復。982Please respect copyright.ＰＥＮＡＮＡDCNKuX7lWo
982Please respect copyright.ＰＥＮＡＮＡF7HWpVg4ti
982Please respect copyright.ＰＥＮＡＮＡH9KG1qmdft
此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。982Please respect copyright.ＰＥＮＡＮＡ2yiC3yQGtk
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。982Please respect copyright.ＰＥＮＡＮＡevdU50Id4t
982Please respect copyright.ＰＥＮＡＮＡMXpYqZOkFN
不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。982Please respect copyright.ＰＥＮＡＮＡSHZuu46GoR
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！982Please respect copyright.ＰＥＮＡＮＡunYuTjSkXC
982Please respect copyright.ＰＥＮＡＮＡ0WMGiBfgOJ
982Please respect copyright.ＰＥＮＡＮＡTMQZr35L5p
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。982Please respect copyright.ＰＥＮＡＮＡsrcgHtzVIq
982Please respect copyright.ＰＥＮＡＮＡaaYa2bGEdl
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc982Please respect copyright.ＰＥＮＡＮＡFD4RbljCWG
982Please respect copyright.ＰＥＮＡＮＡz3lIlPVY0J
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。982Please respect copyright.ＰＥＮＡＮＡPn1hYZVb6r
982Please respect copyright.ＰＥＮＡＮＡbRaUJrIwEE
Link:982Please respect copyright.ＰＥＮＡＮＡud1ibMc5Eo
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio982Please respect copyright.ＰＥＮＡＮＡpv8javusMy
982Please respect copyright.ＰＥＮＡＮＡjwwuN5QKxf
最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。982Please respect copyright.ＰＥＮＡＮＡ7GzNKkY48v
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now982Please respect copyright.ＰＥＮＡＮＡwqUuGnrslO
982Please respect copyright.ＰＥＮＡＮＡhhnnEFsPjN
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。982Please respect copyright.ＰＥＮＡＮＡFTZxoMDBWf
982Please respect copyright.ＰＥＮＡＮＡDNkBZMqin8
Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683
00
ns216.73.216.86da2
