真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。421Please respect copyright.PENANA9n5GkQxAny421Please respect copyright.PENANAc4gaP6ZBpT
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。421Please respect copyright.PENANAu8nCH5YZBe421Please respect copyright.PENANAqdU6F1SMyi
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1.Azole421Please respect copyright.PENANA7Jb1umYdPC
抑制構成細胞膜的Ergosterol產生421Please respect copyright.PENANAj2jmYZq3PI
2. Polyene421Please respect copyright.PENANAiVkNgnNviZ
消耗細胞膜的Ergosterol421Please respect copyright.PENANAcsNWvt74CW
3. Echinocandins421Please respect copyright.PENANAicAz41bIEN
抑制構成細胞外層的糖分組織產生421Please respect copyright.PENANA9eaWjOCvmn
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(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。421Please respect copyright.PENANAFngE9OfhFY421Please respect copyright.PENANAkAgfnJzKt7
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它能夠透過血液循環系統走進全身各部位,引發感染。421Please respect copyright.PENANAnkWBYeQ3vm
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就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。421Please respect copyright.PENANAjdFbgFEaVB
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(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。421Please respect copyright.PENANAn6snUJwjuz421Please respect copyright.PENANAPWADJrRSlj
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Turbinmicin能有效抑制不同真菌品種,包括Candida auris。421Please respect copyright.PENANADzoYwsVDri
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它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。421Please respect copyright.PENANAFIumt4zvae
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它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。421Please respect copyright.PENANAcbwjVQfWf0
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但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。421Please respect copyright.PENANAQE1VPruNjg
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深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。421Please respect copyright.PENANAYbeZjBVuox
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc421Please respect copyright.PENANAYpvEvcdJQR
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio421Please respect copyright.PENANA5KcTfa3ASw
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。421Please respect copyright.PENANA9uJT4zOu9k
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https://www.instagram.com/potatopigtongue/421Please respect copyright.PENANAhG43LKgHmC
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112421Please respect copyright.PENANAvNSeGID9d9
Ref2:https://science.sciencemag.org/content/370/6519/974421Please respect copyright.PENANAEDIctNJlq0