黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。797Please respect copyright.PENANAKNWVkU74Ti797Please respect copyright.PENANAxMCVaUzRYS
797Please respect copyright.PENANA5W95Nb9VwD
它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。797Please respect copyright.PENANAgHI5aYoQpv
797Please respect copyright.PENANAyOXrvmvMKP
(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。797Please respect copyright.PENANA0b6fvvlRKb797Please respect copyright.PENANA8OnOkqIm6H
797Please respect copyright.PENANAATItklq083
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。797Please respect copyright.PENANAhunoLxGz0r
797Please respect copyright.PENANAdxIbuRFsIQ
然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。797Please respect copyright.PENANAvgA6qAUgXe
797Please respect copyright.PENANAF3EXtMese6
(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。797Please respect copyright.PENANAueQsAG4ss0797Please respect copyright.PENANA5lP1cJHc2d
797Please respect copyright.PENANAmkzSnF98z0
(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),797Please respect copyright.PENANAmgzIO37mNq
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。797Please respect copyright.PENANAbv8fSlfDNq797Please respect copyright.PENANAHqzT9qRJVV
797Please respect copyright.PENANAYlTGkBlvFg
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。797Please respect copyright.PENANALkdYoFB5U8
797Please respect copyright.PENANAgLIBpfslcb
797Please respect copyright.PENANAl0ufAjcraS
延伸閱讀:797Please respect copyright.PENANAAMbEWVjb76
深入淺出–從深海生物中發掘出抗真菌藥物797Please respect copyright.PENANAhKO5ILzYMj
- 分享自 LIHKG 討論區797Please respect copyright.PENANA7cn2Gvfg5b
https://lih.kg/2296185797Please respect copyright.PENANAtJQSN2sTSG
797Please respect copyright.PENANAVXVA6yPv2q
797Please respect copyright.PENANAzOddiBiLki
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。797Please respect copyright.PENANAfAPGvb8mAC
797Please respect copyright.PENANADwzlRCp7qH
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc797Please respect copyright.PENANAjUnGVEqb5q
797Please respect copyright.PENANAstMZD57N1b
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。797Please respect copyright.PENANAPJvGvW89xv
797Please respect copyright.PENANAB9SJWqrdhB
Link:797Please respect copyright.PENANAx9KfNL7OQf
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio797Please respect copyright.PENANA0xBfI4bXBo
797Please respect copyright.PENANAKpkF4NVa1r
797Please respect copyright.PENANAimabGVC0qu
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。797Please respect copyright.PENANAUTaMBtilIE
797Please respect copyright.PENANAZVcTlPNDBp
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/797Please respect copyright.PENANAFKCBHx4RLj