黃金葡萄球菌這字眼，周不時亦會在新聞媒體聽得到。793Please respect copyright.ＰＥＮＡＮＡtVEB82lYgf
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它之所以被冠以黃金這稱號，是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin)，以及微量黃色化合物4,4‘-Diaponeurosporene。793Please respect copyright.ＰＥＮＡＮＡh30wuLGARP
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（圖2）當細菌入侵腸道的時候，我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species)，對細菌進行攻擊。793Please respect copyright.ＰＥＮＡＮＡLVFtpeOZVq
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但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素，因此免疫系統所產生的游離基攻擊對它傷害不大。793Please respect copyright.ＰＥＮＡＮＡWxdo74VVym
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然而，如果刪去製作色素的蛋白酶，「黃金」葡萄球菌失去抵擋游離基的手段，對宿主的感染力亦因而大大減低。793Please respect copyright.ＰＥＮＡＮＡBjMR0tsHrU
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（圖3）同時間，若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌，獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強，引證色素對於細菌感染力的重要性。793Please respect copyright.ＰＥＮＡＮＡ1OvsnCGBLK
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（圖4）再舉另外一道例子，Cryptococcus neoformans是一種真菌(fungus)，793Please respect copyright.ＰＥＮＡＮＡvzfBR52cgy
它能夠製作黑色素(Melanin)，亦即是上集所談及決定髮膚眼色的色素。793Please respect copyright.ＰＥＮＡＮＡtlTM8gIjsc
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黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外，其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合，大大削弱藥物傷害真菌的能力。793Please respect copyright.ＰＥＮＡＮＡkoyyUfI1GZ
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延伸閱讀:793Please respect copyright.ＰＥＮＡＮＡqhDLqf0n4I
深入淺出–從深海生物中發掘出抗真菌藥物793Please respect copyright.ＰＥＮＡＮＡOPv2mazvps
- 分享自 LIHKG 討論區793Please respect copyright.ＰＥＮＡＮＡzrCEC5Nr8O
https://lih.kg/2296185793Please respect copyright.ＰＥＮＡＮＡywufA2t0xk
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。793Please respect copyright.ＰＥＮＡＮＡHFssqzY77d
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc793Please respect copyright.ＰＥＮＡＮＡ1DT1ufl3ZL
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。793Please respect copyright.ＰＥＮＡＮＡLIduZCkGwA
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Link:793Please respect copyright.ＰＥＮＡＮＡye16TvE7jn
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio793Please respect copyright.ＰＥＮＡＮＡdSmZ1qqHp3
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。793Please respect copyright.ＰＥＮＡＮＡGCBrurWY8a
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/793Please respect copyright.ＰＥＮＡＮＡTWZj9UCBUu
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