上集略述了心臟肥大與心臟衰竭的關連,今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。573Please respect copyright.PENANANshMc7TWy9573Please respect copyright.PENANAyALBdiV7UN
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上集:https://lih.kg/gOrCdS573Please respect copyright.PENANAFQAGiOo50E
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(圖2)研究發現,當利用縫線手法引致心臟處於肥大狀態的時候,一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。573Please respect copyright.PENANA4WhwCPKc7S573Please respect copyright.PENANAXdQa9YVhxu
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(圖3)當GRK5進入細胞核後,它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動,因而改變其自身的形狀,發揮一系列的功效引致心臟肥大。573Please respect copyright.PENANAmWExUBfcVc573Please respect copyright.PENANAw7FS27kOLM
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見狀,科學家便特意單獨注入其紅色部份到細胞核,目的就是想透過紅色部份的霸佔,阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動,使其功效喪失。573Please respect copyright.PENANAhSpiBLzBtY
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形象化來說,就是某勢力派人霸佔旁聽座位,讓其他人士無法入座。573Please respect copyright.PENANA53R6JZ4yIw
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(圖4)縫線後所引起的心臟肥大,並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。573Please respect copyright.PENANAUnQ2jgCWho573Please respect copyright.PENANASHqhRZY9IM
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最為重要的是,心臟肥大所引起的心肌纖維化(藍色箭嘴),並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。573Please respect copyright.PENANAKifp1Wh3Zo
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換句話說,這GRK5的紅色部份,非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。573Please respect copyright.PENANABlpVHUZYHs
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Ref1:https://stke.sciencemag.org/content/14/676/eabb5968573Please respect copyright.PENANAsudVyVnkYw