減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1054Please respect copyright.ＰＥＮＡＮＡp7msHwXZ9h
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1054Please respect copyright.ＰＥＮＡＮＡfhNs6DDDuW
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1054Please respect copyright.ＰＥＮＡＮＡB0AdwhA3ck
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1054Please respect copyright.ＰＥＮＡＮＡ4S0MWURSaM
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以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1054Please respect copyright.ＰＥＮＡＮＡXxlJckpShX
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相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1054Please respect copyright.ＰＥＮＡＮＡFVExlSsI3o
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老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1054Please respect copyright.ＰＥＮＡＮＡ0hMBKfupFg
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1054Please respect copyright.ＰＥＮＡＮＡQ7SrYQ2x8S
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(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1054Please respect copyright.ＰＥＮＡＮＡJUopPKJe4b
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1054Please respect copyright.ＰＥＮＡＮＡt4UuKnDO8Y
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而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1054Please respect copyright.ＰＥＮＡＮＡW330ZKLnt7
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1054Please respect copyright.ＰＥＮＡＮＡVTvg50aK8H
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1054Please respect copyright.ＰＥＮＡＮＡhzJ6JdAWBi
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1054Please respect copyright.ＰＥＮＡＮＡ6xf5yMnSWZ
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Link:1054Please respect copyright.ＰＥＮＡＮＡw3v6l2Q2I5
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1054Please respect copyright.ＰＥＮＡＮＡBHvhAf0MEQ
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1054Please respect copyright.ＰＥＮＡＮＡUasnqz1Kut
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1054Please respect copyright.ＰＥＮＡＮＡ3NWZd2x9i4
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661054Please respect copyright.ＰＥＮＡＮＡAe7wmwfGo0
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1054Please respect copyright.ＰＥＮＡＮＡiQpdnrfohX
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1054Please respect copyright.ＰＥＮＡＮＡaDaKGasJwA
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1054Please respect copyright.ＰＥＮＡＮＡbLEnlHefyz
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