減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1112Please respect copyright.ＰＥＮＡＮＡB09beKi10T
1112Please respect copyright.ＰＥＮＡＮＡgCYDBPQviU
1112Please respect copyright.ＰＥＮＡＮＡekp00c9xge
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1112Please respect copyright.ＰＥＮＡＮＡZLtaQJaam2
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1112Please respect copyright.ＰＥＮＡＮＡVjmIAVvKEE
1112Please respect copyright.ＰＥＮＡＮＡr7GMqb4D02
1112Please respect copyright.ＰＥＮＡＮＡRXsLCfP2OD
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1112Please respect copyright.ＰＥＮＡＮＡfO6Y94LkM5
1112Please respect copyright.ＰＥＮＡＮＡpPrLhn1vOh
1112Please respect copyright.ＰＥＮＡＮＡwRxuwjMSHq
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1112Please respect copyright.ＰＥＮＡＮＡsbhqGHobcp
1112Please respect copyright.ＰＥＮＡＮＡdeMFkjKujl
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1112Please respect copyright.ＰＥＮＡＮＡfhl9BMb5gt
1112Please respect copyright.ＰＥＮＡＮＡKvGCGIa9II
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1112Please respect copyright.ＰＥＮＡＮＡrodDlJ0cRV
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1112Please respect copyright.ＰＥＮＡＮＡrlXmIs86I1
1112Please respect copyright.ＰＥＮＡＮＡOpVCS1WwHR
1112Please respect copyright.ＰＥＮＡＮＡ4zz7DrlELb
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1112Please respect copyright.ＰＥＮＡＮＡVVwB2gv1cp
1112Please respect copyright.ＰＥＮＡＮＡSPeu9Tczuj
1112Please respect copyright.ＰＥＮＡＮＡQU1zElZ1Uw
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1112Please respect copyright.ＰＥＮＡＮＡTEK2dHfBLh
1112Please respect copyright.ＰＥＮＡＮＡH2kKasdJFR
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1112Please respect copyright.ＰＥＮＡＮＡkI1IZYluvG
1112Please respect copyright.ＰＥＮＡＮＡmW0R0faK66
1112Please respect copyright.ＰＥＮＡＮＡwWhwjpM9wQ
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1112Please respect copyright.ＰＥＮＡＮＡTm56XF7TqX
1112Please respect copyright.ＰＥＮＡＮＡKmGSGXShxI
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1112Please respect copyright.ＰＥＮＡＮＡTTFP32xQWW
1112Please respect copyright.ＰＥＮＡＮＡanl61AQYu1
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1112Please respect copyright.ＰＥＮＡＮＡw0da48HIDu
1112Please respect copyright.ＰＥＮＡＮＡogEhovCQkP
Link:1112Please respect copyright.ＰＥＮＡＮＡ4OITRG0D5W
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1112Please respect copyright.ＰＥＮＡＮＡhMLQjj8hzj
1112Please respect copyright.ＰＥＮＡＮＡ131E8OLd1q
1112Please respect copyright.ＰＥＮＡＮＡkEDgCnlZuP
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1112Please respect copyright.ＰＥＮＡＮＡJ68ZiVuD58
1112Please respect copyright.ＰＥＮＡＮＡwv1XQb4y3e
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1112Please respect copyright.ＰＥＮＡＮＡTTRW4utTfC
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661112Please respect copyright.ＰＥＮＡＮＡnOYDexr7vb
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1112Please respect copyright.ＰＥＮＡＮＡBBSBcq59OV
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1112Please respect copyright.ＰＥＮＡＮＡ15fHFEUxwS
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1112Please respect copyright.ＰＥＮＡＮＡbWpTmcPUfN
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
