這系列的第一集,我們講解了PD1/PDL1的運作原理。1121Please respect copyright.PENANAN4bKkvvBcV
Link: https://www.penana.com/article/4711251121Please respect copyright.PENANAXAGHUVjySY
1121Please respect copyright.PENANAPMkaAWmtDI
第二集我們講述了CTLA4與T cell功用的關係。1121Please respect copyright.PENANAJ85TkdnaBO
Link:https://www.penana.com/article/4724801121Please respect copyright.PENANA4GkYZxNocf
1121Please respect copyright.PENANAyRUGHbFA4s
1121Please respect copyright.PENANADi7YGbUji9
今次第三集這一篇,我們將會講述增加T cell有效抵達癌細胞所在位置的其中一種手段。1121Please respect copyright.PENANADey5mL2ATw
1121Please respect copyright.PENANABYQXVWibOF
(圖2)有不少種類的癌細胞會抑壓與免疫系統相關的機制(RIG-1,JAK,PKR等等),從而盡量減低T cell或免疫細胞前來自身位置的機會。1121Please respect copyright.PENANAN1bAMDdCfA
1121Please respect copyright.PENANA46HVjNl2SB
但免疫系統機制的喪失或銳弱,換來的將會是失去抵禦病毒入侵的能力。1121Please respect copyright.PENANAVLvMw2rTwf
1121Please respect copyright.PENANANv6mVqWONr
1121Please respect copyright.PENANAZ9CZuqEu7U
1121Please respect copyright.PENANATQjnbTUUYq
而能夠在癌細胞裡頭任意進行複製及破壞的病毒,又不會對普通細胞進行過大傷害的,我們稱它為Oncolytic virus。1121Please respect copyright.PENANAYDhgrmxLWw
1121Please respect copyright.PENANALrZeUXdu3Z
這些Oncolytic virus可以是自然存在的病毒,亦可以是被基因改造過的人工病毒。1121Please respect copyright.PENANAKxtzNmt6ep
2006年,中國批准利用Oncolytic virus手段醫治鼻咽癌,而2015年美國FDA及歐洲EMA亦批准這種手段可以用在醫治皮膚癌之上。1121Please respect copyright.PENANAkZWwou3nUX
1121Please respect copyright.PENANAIng5NVKH5u
(圖3)近日有科學家發表文章(Ref1),結合Oncolytic virus及免疫系統治療方式來醫治實驗室細胞及老鼠身上的癌細胞。1121Please respect copyright.PENANAAlqGtk6puR
1121Please respect copyright.PENANA4MC7RYRV1i
1121Please respect copyright.PENANA8T1tqqgKgS
他們利用基因改造方式製作Oncolytic virus,目的就是想細胞被病毒感染後會不斷產生沒有功用的tCD19組件。1121Please respect copyright.PENANAChDd2MGxAp
1121Please respect copyright.PENANAkiMcpgjWZX
在圖中可以清楚看得見,標記為藍色的癌細胞受到病毒感染後,會在自己外圍生產被標記為粉紅色的tCD19組件。1121Please respect copyright.PENANAQlPuj1JT53
1121Please respect copyright.PENANA0xQynREq52
其後,他們製作出能夠辨認tCD19的T cell(整套技術的學術名稱為Chimeric antigen receptor T cell,這裡我們稱之為tCD19-CAR T cell),再放入老鼠身體之內。1121Please respect copyright.PENANAZoCsW8WKBM
1121Please respect copyright.PENANA6aM9PLjAI1
這些tCD19-CAR T cell只會辨認外圍擁有tCD19的細胞,並對其進行殲滅。1121Please respect copyright.PENANAWQ07ZUEuet
1121Please respect copyright.PENANAQgr9KSFAfi
因為tCD19並不自然存在普通細胞裡,所以它們只會殺滅受病毒感染的癌細胞;1121Please respect copyright.PENANAu29edxQjo6
普通健康細胞擁有健全的免疫系統相關機制,因此能夠阻止病毒在自己裡頭繁殖,亦避免了tCD19的產生。1121Please respect copyright.PENANAeMluB6KfhB
1121Please respect copyright.PENANAXg3hUrt1sM
他們在文章清楚顯示,加進Oncolytic virus及tCD19-CAR T cell後能夠有效殺滅老鼠身上的癌細胞。同時他們亦發現得到,癌細胞被殺滅後會同時釋發出病毒,而病毒亦會順之然感染附近的癌細胞,以火燒連環船的方式將tCD19散發開去。1121Please respect copyright.PENANAcjmACqlMUl
1121Please respect copyright.PENANAaytMuDbZUf
這種手段能否在人體上實際運用,還需要一系列的改進及臨床實驗才能得出結論,但無疑的是若然能夠成功配上Oncolytic Virus及CAR Tcell的組合,定必能夠加強免疫細胞鎖定癌細胞所在位置的能力,以三管齊下的方式(PD1/CLTA4/Virus-CARTCell)把癌細胞滅絕。1121Please respect copyright.PENANAPzT1XygYS7
1121Please respect copyright.PENANAVWiwkJzjMR
1121Please respect copyright.PENANAOYaBUx7hr3
1121Please respect copyright.PENANA3JXUBrqYtp
1121Please respect copyright.PENANAPymenj4xi1
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。1121Please respect copyright.PENANAYQeakkV6fq
1121Please respect copyright.PENANAUPXmgaMJEY
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1121Please respect copyright.PENANASEP504fC0d
1121Please respect copyright.PENANAOH9C7qw6Yt
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。1121Please respect copyright.PENANAiLLPRSrn4v
1121Please respect copyright.PENANAR0nt5D4jfg
Link:1121Please respect copyright.PENANAZsn8ddAWin
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1121Please respect copyright.PENANAgau8V96xBx
1121Please respect copyright.PENANAejYGshJJdZ
1121Please respect copyright.PENANAxYw3bGHeXy
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。1121Please respect copyright.PENANAmhYsyFkrpt
1121Please respect copyright.PENANAGsg9kYYn55
Ref1:https://stm.sciencemag.org/content/12/559/eaaz1863