日照工作的時候,我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。547Please respect copyright.PENANA72FvDE4etP
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在睡覺尤其是深層睡眠的時候,我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間, β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈,離開大腦。547Please respect copyright.PENANAC2lSTQiKBv
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夜間工作而日照時間睡覺會否達到同樣效果,暫時未有人體確實數據可以證實。547Please respect copyright.PENANA22LTqiUWyK
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(圖2)睡覺時份,位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助,抵達靜脈排出腦外;547Please respect copyright.PENANAd23g1Z3lb6
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另有研究指出(Ref1),部份的麻醉藥亦能促成同等效果。547Please respect copyright.PENANA7nRObI7mfm
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淋巴系統(Lymphatic System)是排除廢物的系統,基於排除Aβ需要透過星狀細胞的幫助,學術界把整套系統命名為Glympathic system,取其Glial Cell(神經膠質細胞)及Lymphatic System(淋巴系統)的結合,雖則整個機制並沒有淋巴系統的參與(Ref5)。547Please respect copyright.PENANARdRHWAIFwJ
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年老以及神經退化症狀的患者,Glympathic system效率大幅減低,因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話,亦會影響睡眠的質素,形成惡性循環(Ref6)。547Please respect copyright.PENANAQbaC4b6cFy
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對比年輕人士,年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話,患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。547Please respect copyright.PENANAfZ3z9IbFuO
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(圖3)為作進一步了解睡覺與腦部Aβ水平的關係,有研究(Ref2)找來20名人士,分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境,繼而量度Aβ水平。547Please respect copyright.PENANAdbtk4dI85W
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兩種測驗環境之間,測試者平均相隔15日分別進行。結果得出,不論性別歲數,通宵一晚平均將會導致5%的Aβ上升。547Please respect copyright.PENANAMahEV31w51
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(圖4)另外,他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者,發現睡眠質素越高的話,Aβ的移除比率亦會越大。547Please respect copyright.PENANAGFW0nloNk1
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只不過,亦有研究指出睡眠時數少於5小時或多於11的話,認知能力會有衰退傾向,但未知與Aβ是否有關。547Please respect copyright.PENANA1xW132zwn4
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長遠而言,通宵會導致Aβ在腦部的聚積,增加患上神經退化症狀的機會,情況許可的話,可免就則免。547Please respect copyright.PENANATdVSos4h5T
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Ref1:https://advances.sciencemag.org/content/5/2/eaav5447547Please respect copyright.PENANAExrF1yySVE
Ref2:https://www.pnas.org/content/115/17/4483547Please respect copyright.PENANAxPQ14M8ZSj
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/547Please respect copyright.PENANAzmnsjwwj8n
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/547Please respect copyright.PENANAYd5Qhswh6V
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/547Please respect copyright.PENANACdzScDWYhr
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13