減低食慾從而減少進食,某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。803Please respect copyright.PENANAhjbWdB9xY1
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係,803Please respect copyright.PENANAW8VEoz2F4T
其中之一的目標就是設計出一款能壓抑食慾的藥物,輔助癡肥或糖尿病人的治療。803Please respect copyright.PENANAmy2LID9UTz
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。803Please respect copyright.PENANA2CbWBr5Tge
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以非常簡化的角度來說,在飽肚狀態下,含有MC4R蛋白質的神經細胞便會受到刺激,我們的食慾亦會隨之受到壓抑。803Please respect copyright.PENANAAgmALGt9zc
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相反,在飢餓狀態下,含有MC4R蛋白質的神經細胞便會受到壓抑,我們的食慾亦會隨之而來。803Please respect copyright.PENANA4RUatfySvO
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老鼠缺乏MC4R蛋白質的話,體重亦會明顯上升。803Please respect copyright.PENANA9beRnswZqn
而MC4R的蛋白質因基因變異而導致部份功能的喪失,亦能在不少癡肥人士身上記錄得到。803Please respect copyright.PENANA2kiJZei5Ky
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(圖3)刺激MC4R,便能減低食慾,減低食慾,便能減低進食量,有助對抗癡肥。803Please respect copyright.PENANA9LvGREJZri
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用,不得不終止研究及停止發展。803Please respect copyright.PENANAHFZM4pfsdP
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而好消息的是,最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide,並沒有血壓上升的副作用,在符合對應的條件下可用作體重管理之用。803Please respect copyright.PENANAZ6jCfjyz1T
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。803Please respect copyright.PENANAZpWBoLXdko
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc803Please respect copyright.PENANA2gy20JlOx5
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。803Please respect copyright.PENANAqufTYOenPM
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Link:803Please respect copyright.PENANAIYl7HfPfV7
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio803Please respect copyright.PENANA4CDtjn3XjL
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。803Please respect copyright.PENANA9lRTXPqpB2
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/803Please respect copyright.PENANAjZPkTbsoGq
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466803Please respect copyright.PENANAs0kp5uDji6
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/803Please respect copyright.PENANAvt9cM0vEhc
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/803Please respect copyright.PENANAeimWHgvg0H
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/803Please respect copyright.PENANALdnmrwHlQs