皮膚受傷的時候,大多數的情況下都會出現結焦情況,過一段時間後傷口便會縫合。731Please respect copyright.PENANA0sLma0cyN4
731Please respect copyright.PENANA7edJvE43tt
731Please respect copyright.PENANABd3vmOh6FN
有時候,皮膚會留有疤痕,但又有一些情況下會不留痕跡般似的進行修復,就像沒有事發生過一樣。731Please respect copyright.PENANAVi7P1gEXE3
731Please respect copyright.PENANAduVVLqo2ZP
究竟最終會否留有疤痕,是看幸運還是甚麼呢?731Please respect copyright.PENANASENhSchSr9
731Please respect copyright.PENANAiJXXPYB7qo
731Please respect copyright.PENANAUxlAtaKO1c
(圖2)近日,有科學家發表文章(Ref1),對此作出了一個頗為完滿的解答。731Please respect copyright.PENANAzJnL4ghWdC
731Please respect copyright.PENANAg4yFXmINEx
731Please respect copyright.PENANABpN387iZlV
他們在老鼠耳仔上開一個細洞,然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後,傷口會完美修復不留疤。731Please respect copyright.PENANAjgxbNrpQfv
731Please respect copyright.PENANA7IWj7vGJ7J
而在缺乏TRPA1神經細胞的老鼠,就算塗上(IMQ),傷口始終會留有疤痕,表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。731Please respect copyright.PENANAEQs7yaPZU0
731Please respect copyright.PENANAoUPdPk8mee
(圖3)他們進行了一系列的實驗,最終找出了箇中機制,以下為最簡化版本。731Please respect copyright.PENANANHSz168wBa
731Please respect copyright.PENANA5h3mbgSA8r
731Please respect copyright.PENANA7CWHPhoLtm
1.傷口塗上IMQ後,將會引起發炎作用。731Please respect copyright.PENANAPa9LTtLmKQ
2.發炎作用刺激TRPA1神經細胞。731Please respect copyright.PENANAoQxCJAu8xq
3.免疫系統細胞(dermal dendritic cells、γδ T cells)被傳召前來。731Please respect copyright.PENANAU3sJleLTpB
4.免疫系統細胞釋出相關物質(Interlunkin17、22、23)。731Please respect copyright.PENANAl7eKs9migr
5.一系列的過程發生過後,肌膚完美修復。731Please respect copyright.PENANA5UpC0YiuqB
731Please respect copyright.PENANAwnU64VltlK
731Please respect copyright.PENANAfqoQjPpUoX
此研究的結果針對於老鼠的皮膚癒合情況,未必能套用在人類身上,需要作出人體試驗才能廣泛證實此結果。731Please respect copyright.PENANAz5ukDjjgs8
另外,IMQ的塗用時機還需要進一步確認,何時觸發發炎作用才是適當的時機還需要一系列的測試。731Please respect copyright.PENANANGwIgSuOt0
731Please respect copyright.PENANAwPxx1iSXlQ
不過有一點非常重要的是,當人類皮膚受傷的時候,自身是不會主動觸動TRPA1神經細胞。731Please respect copyright.PENANAH62YHMMFGE
若然整個結果能套用在人類身上的話,那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞,觸發一系列的過程使傷口以不留疤痕的方式完美癒合!731Please respect copyright.PENANAPVRhSlbR88
731Please respect copyright.PENANAigPCkM16jG
731Please respect copyright.PENANApg4AkaZP0g
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。731Please respect copyright.PENANAIIX5kFkyp6
731Please respect copyright.PENANAfSPKo87gsM
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc731Please respect copyright.PENANAsWBv0zQlus
731Please respect copyright.PENANA6AKLxvt6Dt
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。731Please respect copyright.PENANAlP1ZiIiZQ9
731Please respect copyright.PENANAbnM0dNwjZD
Link:731Please respect copyright.PENANAUMhpxjENZ1
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio731Please respect copyright.PENANAWtMAugoEfF
731Please respect copyright.PENANA9i88RkkPCC
最後亦請幫一幫忙簽署袁爸的白宮呈請,幫忙為香港出一份力。731Please respect copyright.PENANAZPDObFw8r1
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now731Please respect copyright.PENANA5b3RXUXBvR
731Please respect copyright.PENANANCQ8vKsbPR
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。731Please respect copyright.PENANAS8fQQyIlL9
731Please respect copyright.PENANA9KoQ4HHdd6
Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683
00
ns 172.71.254.42da2