最為理想的檢測武漢肺炎方法,當然是要準確同快速兩者兼備,不需任何儀器家用便能做到為之更佳。558Please respect copyright.PENANAQrqSxJsXfS558Please respect copyright.PENANA22CHZYUWYk
558Please respect copyright.PENANAjP5UCDnWAa
現今最為標準的檢測方法RT-QPCR,但整個過程接近耗時2小時,而且亦需要實驗室PCR儀器及專業人士確認結果的可信性。558Please respect copyright.PENANApkQ9UJgTpW
558Please respect copyright.PENANApj7N7x1A8a
較為快捷但並未全面通行的方法為RT-LAMP,整個過程約耗時30-50分鐘,可套用不同方法展示結果,最高靈敏度比RT-QPCR約低10倍。558Please respect copyright.PENANAEGdlNCgzZY
558Please respect copyright.PENANACfgexNoVdi
整個過程受著需要在攝氏65度運行的限制,距離家用化仍擁有著些許的不便。558Please respect copyright.PENANASvN2LzUz6f
558Please respect copyright.PENANAQjIWrfs9Oq
558Please respect copyright.PENANAWPW3h4YINn
(圖2)最近有科學家研發一套名為SENSR的檢測方法(Ref1),耗時約30-50分鐘,但全程只需在攝氏37度運行!558Please respect copyright.PENANAZWgoOgC2mJ558Please respect copyright.PENANAu4lHilf4V5
558Please respect copyright.PENANAcCC19GHpHG
他們嘗試利用最為準確的RT-QPCR方法作出對比,40個樣本之中,有39個達一致結果。558Please respect copyright.PENANAtTNtpBpq2T
整個檢測方法主要包含四大組件,如圖中所示。558Please respect copyright.PENANA0jRnZmBfL6
558Please respect copyright.PENANApYLCPZMic1
558Please respect copyright.PENANA03xo19e6hP
(圖3)經過精心的設計,兩隻Probes會辨認武肺病毒RNA前後二段位置。558Please respect copyright.PENANASDmTdl8PNo
兩隻Probes同時辨認成功後,名為SplintR ligase的蛋白質便會將兩隻Probes連成一起。558Please respect copyright.PENANAomkLQcHsyj558Please respect copyright.PENANAQUAJWg31vj
558Please respect copyright.PENANA5gWJeQHy9B
558Please respect copyright.PENANAoq5YTB7n3I
(圖4)連成一起的Probe將會被T7 RNA polymerase 利用,生產出特殊結構的物質。558Please respect copyright.PENANATgqCeGyTfW558Please respect copyright.PENANAYKRGqxWuvH
558Please respect copyright.PENANAukJUMe7thN
這些特殊結構物質會Fluroescence Dye結合,發出螢光,而沒有與特殊結構物質結合的Fluroescence Dye則不會發出螢光。558Please respect copyright.PENANARAMhDEpdU7
558Please respect copyright.PENANAtxGnEHnbEM
558Please respect copyright.PENANA2BMtcsCb68
(圖5)只要將病人口水及能夠打破病毒外層的化學物與檢測方法組件放在一起,在攝氏37度的環境下,半小時後便能憑著螢光強度獲取結果。558Please respect copyright.PENANAflfSphMlty558Please respect copyright.PENANAieEfvY8mU9
558Please respect copyright.PENANAMiJeLR7Fx3
沒有螢光,意指沒有武肺病毒的存在。558Please respect copyright.PENANAXSTM5Qy4qe
而螢光越強,則代表武肺病毒數量就越多。558Please respect copyright.PENANAaqhHplkZvC
558Please respect copyright.PENANAS0XOLLuy4C
若然整套檢測方法能長久地與RT-QPCR的結果吻合的話,甚至能改良至更短時間完成的話,那些健康碼或健康護照的系統便完全成為被科技淘汰、多餘無用的產物。558Please respect copyright.PENANA6E1fSjCRif
558Please respect copyright.PENANAYgc3kqAJuA
558Please respect copyright.PENANAJNGbNWLxKC
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。558Please respect copyright.PENANAq5QF3UpYJt
558Please respect copyright.PENANAVckKqqCPzp
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc558Please respect copyright.PENANAwWdi2yGtHq
558Please respect copyright.PENANARpcJRmqsPr
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。558Please respect copyright.PENANAmGwiU6Q3Zc
558Please respect copyright.PENANA3s7Krk3Zkk
Link:558Please respect copyright.PENANAsNNeIF3dp8
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio558Please respect copyright.PENANAZkn6Bu4Mwx
558Please respect copyright.PENANAPDdcacOooA
558Please respect copyright.PENANACBItN7FLq5
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。558Please respect copyright.PENANAqAz4iGCtkx
558Please respect copyright.PENANAM03JTCFlvT
558Please respect copyright.PENANAwStxNCiyAj
Ref1:https://www.nature.com/articles/s41551-020-00617-5.epdf?sharing_token=jyB1FrYxTMs2zz7531NEC9RgN0jAjWel9jnR3ZoTv0Oek8rnwPluVmxh8oas6RXA_yYuSqspJD8rPlYkIjcQAnYsXIpSHTS1rRw2pBOABq2RcPNywJhYXk5RtoOUasrjInaGxrHnZw-U2KJCVSypN2TLCfr8XdJlRq3q0or2Vs8%3D