日照工作的時候,我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。532Please respect copyright.PENANAV1GI0wtd5E
532Please respect copyright.PENANAdwiQGlKS8p
532Please respect copyright.PENANAt6FgZvd9Ll
在睡覺尤其是深層睡眠的時候,我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間, β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈,離開大腦。532Please respect copyright.PENANAg5nJL7Apmn
532Please respect copyright.PENANAByTTJtHClv
夜間工作而日照時間睡覺會否達到同樣效果,暫時未有人體確實數據可以證實。532Please respect copyright.PENANA0wMz9ERaSR
532Please respect copyright.PENANA8zaVeT6Kez
532Please respect copyright.PENANAs6j3AZwnm2
532Please respect copyright.PENANAAHxws6wPeD
(圖2)睡覺時份,位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助,抵達靜脈排出腦外;532Please respect copyright.PENANAiCMpVlwkSS
532Please respect copyright.PENANAYm08BaeGny
另有研究指出(Ref1),部份的麻醉藥亦能促成同等效果。532Please respect copyright.PENANA20jGly6Qny
532Please respect copyright.PENANALeQf7Pc6LO
淋巴系統(Lymphatic System)是排除廢物的系統,基於排除Aβ需要透過星狀細胞的幫助,學術界把整套系統命名為Glympathic system,取其Glial Cell(神經膠質細胞)及Lymphatic System(淋巴系統)的結合,雖則整個機制並沒有淋巴系統的參與(Ref5)。532Please respect copyright.PENANAKnoWuhKEyI
532Please respect copyright.PENANA4jZVsQz4Vc
年老以及神經退化症狀的患者,Glympathic system效率大幅減低,因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話,亦會影響睡眠的質素,形成惡性循環(Ref6)。532Please respect copyright.PENANAVYtPwTMM29
532Please respect copyright.PENANADyMsrU97xd
對比年輕人士,年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話,患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。532Please respect copyright.PENANAcAtKozy6G8
532Please respect copyright.PENANAO5JHni6jwj
532Please respect copyright.PENANApwLn9AeQMY
532Please respect copyright.PENANAeKqtcIZP7g
(圖3)為作進一步了解睡覺與腦部Aβ水平的關係,有研究(Ref2)找來20名人士,分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境,繼而量度Aβ水平。532Please respect copyright.PENANAU66g31iWi3
532Please respect copyright.PENANAcUXdh9aaPo
兩種測驗環境之間,測試者平均相隔15日分別進行。結果得出,不論性別歲數,通宵一晚平均將會導致5%的Aβ上升。532Please respect copyright.PENANAIPjxEaAIqd
532Please respect copyright.PENANAG41ONF4d8L
532Please respect copyright.PENANAzVEDulK3o8
532Please respect copyright.PENANAP54pfw3JKo
(圖4)另外,他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者,發現睡眠質素越高的話,Aβ的移除比率亦會越大。532Please respect copyright.PENANAE9j0jJ2lqZ
532Please respect copyright.PENANAXyzpL5cVOZ
只不過,亦有研究指出睡眠時數少於5小時或多於11的話,認知能力會有衰退傾向,但未知與Aβ是否有關。532Please respect copyright.PENANAbfP5LFVdsx
532Please respect copyright.PENANAFYHF4uv8FK
532Please respect copyright.PENANAsjaeTq6F7q
長遠而言,通宵會導致Aβ在腦部的聚積,增加患上神經退化症狀的機會,情況許可的話,可免就則免。532Please respect copyright.PENANAp6ZJiPfrX5
532Please respect copyright.PENANA2leL7wTJUB
532Please respect copyright.PENANAKpuJzaHDp8
532Please respect copyright.PENANAYuHD1AaKkY
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。532Please respect copyright.PENANAWnrTf31hYA
532Please respect copyright.PENANARHY6pwvbmH
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc532Please respect copyright.PENANAZlOSxaeiow
532Please respect copyright.PENANALYT8CoSctx
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。532Please respect copyright.PENANA0HlU69PLyv
532Please respect copyright.PENANA40bHDBUI8W
Link:532Please respect copyright.PENANAogGsx6V1pa
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio532Please respect copyright.PENANA0R6MecLQDN
532Please respect copyright.PENANAeoU9OvvGRB
532Please respect copyright.PENANA7r23R5tYqV
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。532Please respect copyright.PENANA24w6MKkhWP
532Please respect copyright.PENANA3KvuGoMj7S
Ref1:https://advances.sciencemag.org/content/5/2/eaav5447532Please respect copyright.PENANAQMpplcE1MR
Ref2:https://www.pnas.org/content/115/17/4483532Please respect copyright.PENANAI7l8gX7Xyw
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/532Please respect copyright.PENANAJltHfF6bYC
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/532Please respect copyright.PENANAZJMyqJ3169
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/532Please respect copyright.PENANA7opqiM1P2z
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13